ATP6V0D2

ATP6V0D2
Identifiers
Aliases	ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2, ATP6D2, VMA6, ATPase H+ transporting V0 subunit d2
External IDs	MGI: 1924415 HomoloGene: 72090 GeneCards: ATP6V0D2
Gene ontology Molecular function • protein binding • hydrogen ion transmembrane transporter activity Cellular component • proton-transporting V-type ATPase, V0 domain • endosome • phagocytic vesicle membrane • membrane • early endosome • apical plasma membrane • vacuolar proton-transporting V-type ATPase complex • endosome membrane • extracellular exosome Biological process • insulin receptor signaling pathway • transferrin transport • ion transport • proton transport • ion transmembrane transport • transport • ATP hydrolysis coupled proton transport • regulation of macroautophagy • phagosome acidification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	245972	242341
Ensembl	ENSG00000147614	ENSMUSG00000028238
UniProt	Q8N8Y2	Q80SY3
RefSeq (mRNA)	NM_152565	NM_175406
RefSeq (protein)	NP_689778.1	NP_780615.2
Location (UCSC)	Chr 8: 85.99 – 86.15 Mb	Chr 4: 19.88 – 19.92 Mb
PubMed search	[1]	[2]
Wikidata

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ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 is a protein in humans that is encoded by the ATP6V0D2 gene. ^[3] It is part of proton pumps in the plasma membranes of osteoclasts and aids with extracellular acidification in bone resorption. ^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2". Retrieved 2012-11-12.
4. H, Wu; G, Xu; YP, Li (May 2009). "Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption". Journal of Bone and Mineral Research. 24 (5): 871–885. doi:10.1359/jbmr.081239. PMID 19113919.

Further reading