HLA-B associated transcript 3

BAG6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WX9, 4DWF, 4EEW, 4WWR, 4X86, 2N9P
Identifiers
Aliases	BAG6, BAG-6, BAT3, D6S52E, G3, HLA-B associated transcript 3, BCL2 associated athanogene 6
External IDs	MGI: 1919439 HomoloGene: 3409 GeneCards: BAG6
Gene ontology Molecular function • ribosome binding • misfolded protein binding • Hsp70 protein binding • polyubiquitin binding • proteasome binding • protein binding • ubiquitin-specific protease binding • ubiquitin protein ligase binding Cellular component • cytoplasm • cytosol • membrane • intracellular membrane-bounded organelle • nucleoplasm • BAT3 complex • nucleus Biological process • regulation of apoptotic process • negative regulation of proteolysis • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • cell differentiation • ubiquitin-dependent protein catabolic process • kidney development • embryo development • lung development • immune system process • positive regulation of ERAD pathway • protein stabilization • negative regulation of apoptotic process • internal peptidyl-lysine acetylation • brain development • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • regulation of cell proliferation • synaptonemal complex assembly • spermatogenesis • transport • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • protein localization to cytosolic proteasome complex involved in ERAD pathway • maintenance of unfolded protein involved in ERAD pathway • tail-anchored membrane protein insertion into ER membrane • apoptotic process • covalent chromatin modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7917	224727
Ensembl	n/a	ENSMUSG00000024392
UniProt	P46379	Q9Z1R2
RefSeq (mRNA)	NM_001098534 NM_001199697 NM_001199698 NM_004639 NM_080702 NM_080703	NM_001252468 NM_001252469 NM_057171
RefSeq (protein)	NP_001092004.1 NP_001186626.1 NP_001186627.1 NP_004630.3 NP_542433.1 NP_542434.1	NP_476512.1
Location (UCSC)	Chr 6: 31.64 – 31.65 Mb	Chr 17: 35.14 – 35.15 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Large proline-rich protein BAT3 is a protein that in humans is encoded by the BAT3 gene.^[3][4]

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is a nuclear protein. It has been implicated in the control of apoptosis and regulating heat shock protein. There are three alternatively spliced transcript variants described for this gene.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Banerji J, Sands J, Strominger JL, Spies T (Apr 1990). "A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain". Proc Natl Acad Sci U S A. 87 (6): 2374–8. doi:10.1073/pnas.87.6.2374. PMC 53689. PMID 2156268.
4. "Entrez Gene: BAT3 HLA-B associated transcript 3".

Further reading

• Takayama S, Reed JC (2001). "Molecular chaperone targeting and regulation by BAG family proteins". Nat. Cell Biol. 3 (10): E237–41. doi:10.1038/ncb1001-e237. PMID 11584289.
• Cross SJ, Tonks S, Trowsdale J, Campbell RD (1992). "Novel detection of restriction fragment length polymorphisms in the human major histocompatibility complex". Immunogenetics. 34 (6): 376–84. doi:10.1007/BF01787488. PMID 1684176.
• Spies T, Bresnahan M, Strominger JL (1989). "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8955–8. doi:10.1073/pnas.86.22.8955. PMC 298409. PMID 2813433.
• Spies T, Blanck G, Bresnahan M, et al. (1989). "A new cluster of genes within the human major histocompatibility complex". Science. 243 (4888): 214–7. doi:10.1126/science.2911734. PMID 2911734.
• Ozaki T, Hanaoka E, Naka M, et al. (1999). "Cloning and characterization of rat BAT3 cDNA". DNA Cell Biol. 18 (6): 503–12. doi:10.1089/104454999315222. PMID 10390159.
• Thress K, Song J, Morimoto RI, Kornbluth S (2001). "Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper". EMBO J. 20 (5): 1033–41. doi:10.1093/emboj/20.5.1033. PMC 145500. PMID 11230127.
• Manchen ST, Hubberstey AV (2001). "Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosis". Biochem. Biophys. Res. Commun. 287 (5): 1075–82. doi:10.1006/bbrc.2001.5701. PMID 11587531.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Wu YH, Shih SF, Lin JY (2004). "Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3". J. Biol. Chem. 279 (18): 19264–75. doi:10.1074/jbc.M307049200. PMID 14960581.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Kumar R, Lutz W, Frank E, Im HJ (2004). "Immediate early gene X-1 interacts with proteins that modulate apoptosis". Biochem. Biophys. Res. Commun. 323 (4): 1293–8. doi:10.1016/j.bbrc.2004.09.006. PMC 2895269. PMID 15451437.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.