Benzthiazide

Benzthiazide
Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	none
Legal status
Legal status	℞ (Prescription only)
Pharmacokinetic data
Bioavailability	60 to 70%
Protein binding	30%
Biological half-life	5 to 15 hours
Excretion	Renal
Identifiers
IUPAC name 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)- 4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
CAS Number	91-33-8^Y
PubChem (CID)	2343
IUPHAR/BPS	7125
DrugBank	DB00562^Y
ChemSpider	2253^Y
UNII	1TD8J48L61^Y
KEGG	D00651^Y
ChEBI	CHEBI:3047^Y
ChEMBL	CHEMBL1201039^N
Chemical and physical data
Formula	C₁₅H₁₄ClN₃O₄S₃
Molar mass	431.94 g/mol
3D model (Jmol)	Interactive image
SMILES O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)/N=C(\N2)CSCc3ccccc3)N
InChI InChI=1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21)^Y Key:NDTSRXAMMQDVSW-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Benzthiazide (BAN/INN, also known as benzothiazide; trade names Aquatag, Dihydrex, Diucen, Edemax, Exna, Foven and others^[1]) is a thiazide diuretic used in the treatment of high blood pressure and edema. It is no longer available in the United States.

In the United Kingdom, it was also sold in combination with the potassium-sparing diuretic triamterene under the trade name Dytide.^[2] The same combination is still available in Switzerland as Dyrenium compositum.^[3]

References

↑ David J. Triggle; C. R. Ganellin; F. MacDonald (1996). Dictionary of Pharmacological Agents. 1. Boca Raton: Chapman & Hall/CRC. p. 246. ISBN 0-412-46630-9. Retrieved on August 29, 2008 through Google Book Search.
↑ "Triamterene and Benzthiazide". PatientUK. 2005. Retrieved 2008-08-29.
↑ "Dyrenium compositum". Doetsch Grether. n.d. Archived from the original on February 11, 2007. Retrieved 2008-08-29.

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