CALCOCO2

CALCOCO2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3VVV, 3VVW, 4GXL, 4HAN, 2MXP, 4XKL
Identifiers
Aliases	CALCOCO2, NDP52, calcium binding and coiled-coil domain 2
External IDs	HomoloGene: 31339 GeneCards: CALCOCO2
Gene ontology Molecular function • protein binding • protein homodimerization activity Cellular component • cytoplasm • perinuclear region of cytoplasm • autophagosome • autophagosome membrane • cytoskeleton • membrane • cytoplasmic vesicle • nucleus • intracellular membrane-bounded organelle Biological process • autophagy • viral process • positive regulation of autophagosome maturation • response to interferon-gamma • xenophagy Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10241	n/a
Ensembl	ENSG00000136436	n/a
UniProt	Q13137	n/a
RefSeq (mRNA)	NM_001261390 NM_001261391 NM_001261393 NM_001261395 NM_005831	n/a
RefSeq (protein)	NP_001248319.1 NP_001248320.1 NP_001248322.1 NP_001248324.1 NP_005822.1	n/a
Location (UCSC)	Chr 17: 48.83 – 48.87 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Calcium-binding and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the CALCOCO2 gene.^[2][3]

The protein encoded by this gene is a subunit of nuclear domain 10 (ND10) bodies. ND10 bodies are nuclear domains appearing immunohistochemically as ten dots per nucleus. They are believed to be associated with the nuclear matrix on the basis of their resistance to nuclease digestion and salt extraction. ND10 proteins are removed from the nucleus by herpes simplex virus-1 infection and may have a role in viral life cycles.^[3]

References

1. "Human PubMed Reference:".
2. Korioth F, Gieffers C, Maul GG, Frey J (Jul 1995). "Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment". J Cell Biol. 130 (1): 1–13. doi:10.1083/jcb.130.1.1. PMC 2120522. PMID 7540613.
3. "Entrez Gene: CALCOCO2 calcium binding and coiled-coil domain 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Sternsdorf T, Jensen K, Züchner D, Will H (1997). "Cellular localization, expression, and structure of the nuclear dot protein 52.". J. Cell Biol. 138 (2): 435–48. doi:10.1083/jcb.138.2.435. PMC 2138200. PMID 9230084.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Florin L, Schäfer F, Sotlar K, et al. (2002). "Reorganization of nuclear domain 10 induced by papillomavirus capsid protein l2.". Virology. 295 (1): 97–107. doi:10.1006/viro.2002.1360. PMID 12033769.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Di Y, Li J, Zhang Y, et al. (2004). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins.". J. Biochem. 133 (6): 713–8. doi:10.1093/jb/mvg091. PMID 12869526.
• Everett RD, Sourvinos G, Leiper C, et al. (2004). "Formation of nuclear foci of the herpes simplex virus type 1 regulatory protein ICP4 at early times of infection: localization, dynamics, recruitment of ICP27, and evidence for the de novo induction of ND10-like complexes.". J. Virol. 78 (4): 1903–17. doi:10.1128/JVI.78.4.1903-1917.2004. PMC 369473. PMID 14747555.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Morriswood B, Ryzhakov G, Puri C, et al. (2007). "T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion.". J. Cell. Sci. 120 (Pt 15): 2574–85. doi:10.1242/jcs.007005. PMC 2621013. PMID 17635994.

External links

• CALCOCO2 human gene location in the UCSC Genome Browser.
• CALCOCO2 human gene details in the UCSC Genome Browser.