CALHM1

CALHM1
Identifiers
Aliases	CALHM1, FAM26C, calcium homeostasis modulator 1
External IDs	MGI: 3643383 HomoloGene: 55508 GeneCards: CALHM1
Gene ontology Molecular function • voltage-gated calcium channel activity • calcium activated cation channel activity • calcium channel activity • voltage-gated ion channel activity • identical protein binding Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • plasma membrane • integral component of plasma membrane • endoplasmic reticulum Biological process • sensory perception of umami taste • ATP transport • regulation of ion transmembrane transport • cation transport • ion transport • sensory perception of bitter taste • calcium ion transmembrane transport • transport • sensory perception of sweet taste • protein homooligomerization • sensory perception of taste • calcium ion transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	255022	546729
Ensembl	ENSG00000185933	ENSMUSG00000079258
UniProt	Q8IU99	D3Z291
RefSeq (mRNA)	NM_001001412	NM_001081271
RefSeq (protein)	NP_001001412.3	NP_001074740.1
Location (UCSC)	Chr 10: 103.45 – 103.46 Mb	Chr 19: 47.14 – 47.14 Mb
PubMed search	[1]	[2]
Wikidata

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Calcium homeostasis modulator 1 (CALHM1) is a pore-forming subunit of a voltage-gated ion channel that in humans is encoded by the CALHM1 gene.^[3]

Function

Central nervous system

CALHM1 was identified by a tissue-specific gene expression profiling approach^[4] that screened for genes located on susceptibility loci for late-onset Alzheimer's disease (AD) and that are preferentially expressed in the hippocampus,^[3] a brain region affected early in AD. CALHM1 is a plasma membrane calcium-permeable ion channel regulated by voltage and extracellular calcium levels.^[5] The exact function of CALHM1 in the brain is not completely understood, but studies have shown that CALHM1 controls neuronal intracellular calcium homeostasis and signaling, as well as calcium-dependent neuronal excitability.^[5][6] Recent data have also shown that CALHM1 might facilitate the proteolytic degradation of the cerebral amyloid beta peptide, a culprit in AD pathogenesis.^[7]

Peripheral taste system

CALHM1 is expressed in taste bud cells where it controls purinergic receptor-mediated taste transduction in the gustatory system.^[8][9]

See also

• Ruthenium red

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Dreses-Werringloer U, Lambert JC, Vingtdeux V, Zhao H, Vais H, Siebert A, Jain A, Koppel J, Rovelet-Lecrux A, Hannequin D, Pasquier F, Galimberti D, Scarpini E, Mann D, Lendon C, Campion D, Amouyel P, Davies P, Foskett JK, Campagne F, Marambaud P (Jun 2008). "A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk". Cell. 133 (7): 1149–61. doi:10.1016/j.cell.2008.05.048. PMID 18585350.
4. Skrabanek L, Campagne F (Nov 2001). "TissueInfo: high-throughput identification of tissue expression profiles and specificity". Nucleic Acids Research. 29 (21): E102–2. doi:10.1093/nar/29.21.e102. PMC 60201. PMID 11691939.
5. Ma Z, Siebert AP, Cheung KH, Lee RJ, Johnson B, Cohen AS, Vingtdeux V, Marambaud P, Foskett JK (Jul 2012). "Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability". Proceedings of the National Academy of Sciences of the United States of America. 109 (28): E1963–71. doi:10.1073/pnas.1204023109. PMID 22711817.
6. Dreses-Werringloer U, Vingtdeux V, Zhao H, Chandakkar P, Davies P, Marambaud P (Mar 2013). "CALHM1 controls the Ca²⁺-dependent MEK, ERK, RSK and MSK signaling cascade in neurons". J Cell Sci. 126: 1199–206. doi:10.1242/jcs.117135. PMID 23345406.
7. Vingtdeux V, Chandakkar P, Zhao H, Blanc L, Ruiz S, Marambaud P (May 2015). "CALHM1 ion channel elicits amyloid-β clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brain". J Cell Sci. 128: 2330–8. doi:10.1242/jcs.167270. PMID 25999473.
8. Taruno A, Vingtdeux V, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, Adrien L, Zhao H, Leung S, Abernethy M, Koppel J, Davies P, Civan MM, Chaudhari N, Matsumoto I, Hellekant G, Tordoff MG, Marambaud P, Foskett JK (Mar 2013). "CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes". Nature. 495 (7440): 223–6. doi:10.1038/nature11906. PMID 23467090.
9. Kinnamon SC, Finger TE (Dec 2013). "A taste for ATP: neurotransmission in taste buds". Front Cell Neurosci. 18 (7): 264. doi:10.3389/fncel.2013.00264. PMID 24385952.

Further reading

• Moyer BD, Hevezi P, Gao N, Lu M, Kalabat D, Soto H, Echeverri F, Laita B, Yeh SA, Zoller M, Zlotnik A (Dec 2009). "Expression of genes encoding multi-transmembrane proteins in specific primate taste cell populations". PLOS ONE. 4 (12): e7682. doi:10.1371/journal.pone.0007682. PMC 2780358. PMID 19997627.
• Moreno-Ortega AJ, Ruiz-Nuño A, García AG, Cano-Abad MF (Jan 2010). "Mitochondria sense with different kinetics the calcium entering into HeLa cells through calcium channels CALHM1 and mutated P86L-CALHM1". Biochemical and Biophysical Research Communications. 391 (1): 722–6. doi:10.1016/j.bbrc.2009.11.127. PMID 19944073.
• Desharnais R, Godin G, Jobin J, Valois P, Ross A (Dec 1990). "Optimism and health-relevant cognitions after a myocardial infarction". Psychological Reports. 67 (3 Pt 2): 247–55. doi:10.3233/JAD-2010-100933. PMID 2084739.
• Lv RJ, He JS, Fu YH, Shao XQ, Wu LW, Lu Q, Jin LR, Liu H (Apr 2011). "A polymorphism in CALHM1 is associated with temporal lobe epilepsy". Epilepsy & Behavior. 20 (4): 681–5. doi:10.1016/j.yebeh.2011.02.007. PMID 21439911.