CIC (gene)

CIC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M41, 4J2J, 4J2L
Identifiers
Aliases	CIC
External IDs	MGI: 1918972 HomoloGene: 87637 GeneCards: CIC
Gene ontology Molecular function • DNA binding • protein binding • chromatin binding Cellular component • nucleus Biological process • transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated • lung alveolus development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23152	71722
Ensembl	ENSG00000079432	ENSMUSG00000005442
UniProt	Q96RK0	Q924A2
RefSeq (mRNA)	NM_001304815 NM_015125	NM_001110131 NM_001110132 NM_027882 NM_001302811
RefSeq (protein)	NP_001291744.1 NP_055940.3	NP_001289740.1 NP_082158.2
Location (UCSC)	Chr 19: 42.27 – 42.3 Mb	Chr 7: 25.27 – 25.29 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Protein capicua homolog is a protein that in humans is encoded by the CIC gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Lee CJ, Chan WI, Cheung M, Cheng YC, Appleby VJ, Orme AT, Scotting PJ (Oct 2002). "CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons". Brain Res Mol Brain Res. 106 (1–2): 151–6. doi:10.1016/S0169-328X(02)00439-4. PMID 12393275.
4. Lee CJ, Chan WI, Scotting PJ (Jun 2005). "CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas". J Neurooncol. 73 (2): 101–8. doi:10.1007/s11060-004-4598-2. PMID 15981098.
5. "Entrez Gene: CIC capicua transcriptional repressor [ Homo sapiens (human) ]".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.