CLDN12

CLDN12
Identifiers
Aliases	CLDN12
External IDs	MGI: 1929288 HomoloGene: 40809 GeneCards: CLDN12
Gene ontology Molecular function • structural molecule activity • identical protein binding Cellular component • integral component of membrane • cell junction • plasma membrane • lateral plasma membrane • membrane • cell periphery • bicellular tight junction Biological process • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9069	64945
Ensembl	ENSG00000157224	ENSMUSG00000046798
UniProt	P56749	Q9ET43
RefSeq (mRNA)	NM_012129 NM_001185072 NM_001185073	NM_001193659 NM_001193660 NM_001193661 NM_022890
RefSeq (protein)	NP_001172001.1 NP_001172002.1 NP_036261.1	NP_001180588.1 NP_001180589.1 NP_001180590.1 NP_075028.1
Location (UCSC)	Chr 7: 90.38 – 90.51 Mb	Chr 5: 5.49 – 5.51 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Claudin-12 is a protein that in humans is encoded by the CLDN12 gene.^[3] It belongs to the group of claudins.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: CLDN12 claudin 12".

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier.". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport.". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions.". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets.". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins.". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Niimi T, Nagashima K, Ward JM, et al. (2001). "claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing.". Mol. Cell. Biol. 21 (21): 7380–90. doi:10.1128/MCB.21.21.7380-7390.2001. PMC 99911. PMID 11585919.
• Kiuchi-Saishin Y, Gotoh S, Furuse M, et al. (2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments.". J. Am. Soc. Nephrol. 13 (4): 875–86. PMID 11912246.
• Brandner JM, Kief S, Grund C, et al. (2003). "Organization and formation of the tight junction system in human epidermis and cultured keratinocytes.". Eur. J. Cell Biol. 81 (5): 253–63. doi:10.1078/0171-9335-00244. PMID 12067061.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Kitajiri SI, Furuse M, Morita K, et al. (2004). "Expression patterns of claudins, tight junction adhesion molecules, in the inner ear.". Hear. Res. 187 (1–2): 25–34. doi:10.1016/S0378-5955(03)00338-1. PMID 14698084.
• Acharya P, Beckel J, Ruiz WG, et al. (2004). "Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium.". Am. J. Physiol. Renal Physiol. 287 (2): F305–18. doi:10.1152/ajprenal.00341.2003. PMID 15068973.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. doi:10.1021/acs.jproteome.5b00769. PMID 26680015.