CLEC1B

CLEC1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C6U, 3WSR, 3WWK
Identifiers
Aliases	CLEC1B, 1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721, C-type lectin domain family 1 member B
External IDs	MGI: 1913287 HomoloGene: 49468 GeneCards: CLEC1B
Gene ontology Molecular function • protein binding • transmembrane signaling receptor activity • carbohydrate binding Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • platelet activation • defense response • cell surface receptor signaling pathway • platelet formation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51266	56760
Ensembl	ENSG00000165682	ENSMUSG00000030159
UniProt	Q9P126	Q9JL99
RefSeq (mRNA)	NM_001099431 NM_016509	NM_001204239 NM_001204253 NM_019985
RefSeq (protein)	NP_001092901.1 NP_057593.3	NP_001191168.1 NP_064369.1
Location (UCSC)	Chr 12: 9.99 – 10.01 Mb	Chr 6: 129.4 – 129.41 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.^[3][4][5]

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM]^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol. 30 (2): 697–704. doi:10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M. PMID 10671229.
4. Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol. 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID 11745369.
5. "Entrez Gene: CLEC1B C-type lectin domain family 1, member B".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki-Inoue K, Fuller GL, García A, et al. (2006). "A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2". Blood. 107 (2): 542–9. doi:10.1182/blood-2005-05-1994. PMID 16174766.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Watson AA, O'Callaghan CA (2006). "Crystallization and X-ray diffraction analysis of human CLEC-2". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 12): 1094–6. doi:10.1107/S1744309105037991. PMC 1978148. PMID 16511244.
• Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.
• Chaipan C, Soilleux EJ, Simpson P, et al. (2006). "DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets". J. Virol. 80 (18): 8951–60. doi:10.1128/JVI.00136-06. PMC 1563896. PMID 16940507.
• Watson AA, Brown J, Harlos K, et al. (2007). "The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2". J. Biol. Chem. 282 (5): 3165–72. doi:10.1074/jbc.M610383200. PMID 17132623.
• Suzuki-Inoue K, Kato Y, Inoue O, et al. (2007). "Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells". J. Biol. Chem. 282 (36): 25993–6001. doi:10.1074/jbc.M702327200. PMID 17616532.
• Watson AA, Eble JA, O'Callaghan CA (2008). "Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2". Prot. Sci. 17 (9): 1611–6. doi:10.1110/ps.035568.108. PMC 2525532. PMID 18583525.