CORO2A

CORO2A
Identifiers
Aliases	CORO2A, CLIPINB, IR10, WDR2, coronin 2A
External IDs	MGI: 1345966 HomoloGene: 2546 GeneCards: CORO2A
Gene ontology Molecular function • actin binding • actin filament binding Cellular component • actin cytoskeleton • transcriptional repressor complex Biological process • actin cytoskeleton organization • intracellular signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7464	107684
Ensembl	ENSG00000106789	ENSMUSG00000028337
UniProt	Q92828	Q8C0P5
RefSeq (mRNA)	NM_003389 NM_052820	NM_001164804 NM_178893
RefSeq (protein)	NP_003380.3 NP_438171.1	NP_001158276.1 NP_849224.2
Location (UCSC)	Chr 9: 98.12 – 98.19 Mb	Chr 4: 46.54 – 46.6 Mb
PubMed search	[1]	[2]
Wikidata

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Coronin, actin binding protein, 2A is a protein that in humans is encoded by the CORO2A gene.^[3]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Coronin, actin binding protein, 2A". Retrieved 2012-01-03.

Further reading

• Yoon, H. -G.; Chan, D. W.; Huang, Z. Q.; Li, J.; Fondell, J. D.; Qin, J.; Wong, J. (2003). "Purification and functional characterization of the human N-CoR complex: The roles of HDAC3, TBL1 and TBLR1". The EMBO Journal. 22 (6): 1336–1346. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
• Yoon, H. G.; Chan, D. W.; Reynolds, A. B.; Qin, J.; Wong, J. (2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell. 12 (3): 723–734. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
• Marshall, T. W.; Aloor, H. L.; Bear, J. E. (2009). "Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway". Journal of Cell Science. 122 (17): 3061–3069. doi:10.1242/jcs.051482. PMC 2729258. PMID 19654210.
• Jin, Y.; Birlea, S. A.; Fain, P. R.; Mailloux, C. M.; Riccardi, S. L.; Gowan, K.; Holland, P. J.; Bennett, D. C.; Wallace, M. R.; McCormack, W. T.; Kemp, E. H.; Gawkrodger, D. J.; Weetman, A. P.; Picardo, M.; Leone, G.; Taïeb, A.; Jouary, T.; Ezzedine, K.; Van Geel, N.; Lambert, J.; Overbeck, A.; Spritz, R. A. (2010). "Common variants in FOXP1 are associated with generalized vitiligo". Nature Genetics. 42 (7): 576–578. doi:10.1038/ng.602. PMC 2893242. PMID 20526340.
• Zaphiropoulos, P. G.; Toftgård, R. (1996). "CDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region". DNA and cell biology. 15 (12): 1049–1056. doi:10.1089/dna.1996.15.1049. PMID 8985118.