CTDSP1

CTDSP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T9Z, 1TA0, 2GHQ, 2GHT, 3L0B, 3L0C, 3L0Y, 3PGL, 4YGY, 4YH1
Identifiers
Aliases	CTDSP1, NIF3, NLI-IF, NLIIF, SCP1, CTD small phosphatase 1
External IDs	MGI: 2654470 HomoloGene: 100834 GeneCards: CTDSP1
Gene ontology Molecular function • phosphatase activity • CTD phosphatase activity • protein binding • phosphoprotein phosphatase activity • hydrolase activity • metal ion binding Cellular component • extracellular exosome • nucleus • nucleoplasm Biological process • regulation of transcription from RNA polymerase II promoter • negative regulation of G1/S transition of mitotic cell cycle • negative regulation of protein phosphorylation • negative regulation of neurogenesis • protein dephosphorylation • negative regulation of neuron differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	58190	227292
Ensembl	ENSG00000144579	ENSMUSG00000026176
UniProt	Q9GZU7	P58466
RefSeq (mRNA)	NM_001206878 NM_001206879 NM_021198 NM_182642	NM_153088
RefSeq (protein)	NP_001193807.1 NP_067021.1 NP_872580.1	NP_694728.1
Location (UCSC)	Chr 2: 218.4 – 218.41 Mb	Chr 1: 74.39 – 74.4 Mb
PubMed search	[1]	[2]
Wikidata

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Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 is an enzyme that in humans is encoded by the CTDSP1 gene.^[3][4][5]

Interactions

CTDSP1 has been shown to interact with SNAI1.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Ma X, Wright J, Dou S, Olsen P, Teeter L, Adams G, Graviss E (Apr 2002). "Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility". J Hum Genet. 47 (3): 140–5. doi:10.1007/s100380200016. PMID 11950066.
4. Yeo M, Lin PS, Dahmus ME, Gill GN (Jul 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". J Biol Chem. 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
5. "Entrez Gene: CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1".
6. Wu, Yadi; Evers B Mark; Zhou Binhua P (Jan 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". J. Biol. Chem. United States. 284 (1): 640–8. doi:10.1074/jbc.M806916200. ISSN 0021-9258. PMC 2610500. PMID 19004823.

Further reading

• Marquet S, Lepage P, Hudson TJ, et al. (2000). "Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35.". Mamm. Genome. 11 (9): 755–62. doi:10.1007/s003350010151. PMID 10967134.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fernandes AO, Campagnoni CW, Kampf K, et al. (2004). "Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor in the nervous system.". J. Neurosci. Res. 75 (4): 461–71. doi:10.1002/jnr.10882. PMID 14743429.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yeo M, Lee SK, Lee B, et al. (2005). "Small CTD phosphatases function in silencing neuronal gene expression.". Science. 307 (5709): 596–600. doi:10.1126/science.1100801. PMID 15681389.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Sapkota G, Knockaert M, Alarcón C, et al. (2007). "Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways.". J. Biol. Chem. 281 (52): 40412–9. doi:10.1074/jbc.M610172200. PMID 17085434.