CYB5R2

CYB5R2
Identifiers
Aliases	CYB5R2, B5R.2, cytochrome b5 reductase 2
External IDs	MGI: 2444415 HomoloGene: 6182 GeneCards: CYB5R2
Gene ontology Molecular function • oxidoreductase activity • protein binding • cytochrome-b5 reductase activity, acting on NAD(P)H • FAD binding Cellular component • nucleus • membrane • endoplasmic reticulum membrane • mitochondrion Biological process • steroid metabolic process • sterol biosynthetic process • steroid biosynthetic process • lipid metabolic process • bicarbonate transport • oxidation-reduction process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51700	320635
Ensembl	ENSG00000166394	ENSMUSG00000048065
UniProt	Q6BCY4	Q3KNK3
RefSeq (mRNA)	NM_001001336 NM_001302826 NM_001302827 NM_016229	NM_001205227 NM_177216
RefSeq (protein)	NP_001289755.1 NP_057313.2	NP_001192156.1 NP_796190.1
Location (UCSC)	Chr 11: 7.67 – 7.68 Mb	Chr 7: 107.75 – 107.76 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Cytochrome b5 reductase 2 is an enzyme that in humans is encoded by the CYB5R2 gene.^[3][4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: cytochrome b5 reductase 2".
4. Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (December 1999). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14742–7. doi:10.1073/pnas.96.26.14742. PMC 24718. PMID 10611283.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Heard-Costa NL, Zillikens MC, Monda KL; et al. (2009). Dermitzakis, Emmanouil T., ed. "NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium". PLoS Genet. 5 (6): e1000539. doi:10.1371/journal.pgen.1000539. PMC 2695005. PMID 19557197.
• Zhu H, Qiu H, Yoon HW, et al. (1999). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14742–7. doi:10.1073/pnas.96.26.14742. PMC 24718. PMID 10611283.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Baker MA, Krutskikh A, Curry BJ, et al. (2005). "Identification of cytochrome-b5 reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa". Biol. Reprod. 73 (2): 334–42. doi:10.1095/biolreprod.104.037960. PMID 15858218.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.