Calcyphosin

CAPS
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3E3R
Identifiers
Aliases	CAPS, CAPS1, calcyphosine
External IDs	HomoloGene: 37871 GeneCards: CAPS
Gene ontology Molecular function • calcium ion binding • metal ion binding Cellular component • cytoplasm • vesicle • plasma membrane • extracellular exosome • nucleus Biological process • mitophagy in response to mitochondrial depolarization • intracellular signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	828	n/a
Ensembl	n/a	n/a
UniProt	Q13938	n/a
RefSeq (mRNA)	NM_004058 NM_080590	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	Chr 19: 5.91 – 5.92 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Calcyphosin is a protein that in humans is encoded by the CAPS gene.^[2][3][4]

Function

This gene encodes a calcium-binding protein, which may play a role in the regulation of ion transport. A similar protein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5 antigen in rabbit. Alternative splicing of this gene generates two transcript variants.^[4]

References

1. "Human PubMed Reference:".
2. El Housni H, Radulescu A, Lecocq R, Dumont JE, Christophe D (Aug 1997). "Cloning and sequence analysis of human calcyphosine complementary DNA". Biochim Biophys Acta. 1352 (3): 249–52. doi:10.1016/s0167-4781(97)00073-0. PMID 9224948.
3. Lefort A, Passage E, Libert F, Szpirer J, Vassart G, Mattei MG (Feb 1991). "Localization of human calcyphosine gene (CAPS) to the p13.3 region of chromosome 19 by in situ hybridization". Cytogenet Cell Genet. 54 (3-4): 154–5. doi:10.1159/000132981. PMID 2265558.
4. "Entrez Gene: CAPS calcyphosine".

Further reading

• Lefort A, Lecocq R, Libert F, et al. (1989). "Cloning and sequencing of a calcium-binding protein regulated by cyclic AMP in the thyroid.". EMBO J. 8 (1): 111–6. PMC 400778. PMID 2540953.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Clément S, Dumont JE, Schurmans S (1997). "Loss of calcyphosine gene expression in mouse and other rodents.". Biochem. Biophys. Res. Commun. 232 (2): 407–13. doi:10.1006/bbrc.1997.6297. PMID 9125191.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.