DCTN3

DCTN3
Identifiers
Aliases	DCTN3, DCTN-22, DCTN22, dynactin subunit 3
External IDs	MGI: 1859251 HomoloGene: 5233 GeneCards: DCTN3
Gene ontology Molecular function • structural molecule activity • protein binding Cellular component • cytoplasm • condensed chromosome kinetochore • cytosol • centrosome • dynactin complex • spindle • chromosome • microtubule organizing center • microtubule associated complex • midbody • perinuclear region of cytoplasm • cleavage furrow • chromosome, centromeric region • cytoskeleton • kinetochore Biological process • mitotic nuclear division • antigen processing and presentation of exogenous peptide antigen via MHC class II • cytokinesis • cell division • ER to Golgi vesicle-mediated transport • G2/M transition of mitotic cell cycle • microtubule-based process • cell cycle Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11258	53598
Ensembl	ENSG00000137100	ENSMUSG00000028447
UniProt	O75935	Q9Z0Y1
RefSeq (mRNA)	NM_024348 NM_001281425 NM_001281426 NM_001281427 NM_007234	NM_001159565 NM_016890
RefSeq (protein)	NP_001268354.1 NP_001268355.1 NP_009165.1 NP_077324.1	NP_001153037.1 NP_058586.3
Location (UCSC)	Chr 9: 34.61 – 34.62 Mb	Chr 4: 41.71 – 41.72 Mb
PubMed search	[1]	[2]
Wikidata

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Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene.^[3][4][5]

This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Karki S, LaMonte B, Holzbaur EL (Sep 1998). "Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells". J Cell Biol. 142 (4): 1023–34. doi:10.1083/jcb.142.4.1023. PMC 2132867. PMID 9722614.
4. Mills DR, Jackson CL (Apr 2001). "Assignment of p22 dynactin light chain (DCTN3) to human chromosome region 9p13 by radiation hybrid mapping". Cytogenet Cell Genet. 92 (1-2): 166. doi:10.1159/000056892. PMID 11306820.
5. "Entrez Gene: DCTN3 dynactin 3 (p22)".

Further reading

• Karki S, Tokito MK, Holzbaur EL (2000). "A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1.". J. Biol. Chem. 275 (7): 4834–9. doi:10.1074/jbc.275.7.4834. PMID 10671518.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.