DGAT1

DGAT1
Identifiers
Aliases	DGAT1, ARAT, ARGP1, DGAT, DIAR7, diacylglycerol O-acyltransferase 1
External IDs	MGI: 1333825 HomoloGene: 7688 GeneCards: DGAT1
EC number	2.3.1.76
Gene ontology Molecular function • transferase activity • O-acyltransferase activity • protein binding • 2-acylglycerol O-acyltransferase activity • retinol O-fatty-acyltransferase activity • transferase activity, transferring acyl groups • diacylglycerol O-acyltransferase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • endoplasmic reticulum Biological process • glycerolipid metabolic process • retinol metabolic process • lipid storage • fatty acid homeostasis • diacylglycerol metabolic process • triglyceride biosynthetic process • very-low-density lipoprotein particle assembly • long-chain fatty-acyl-CoA metabolic process • triglyceride metabolic process • acylglycerol acyl-chain remodeling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8694	13350
Ensembl	ENSG00000185000	ENSMUSG00000022555
UniProt	O75907	Q9Z2A7
RefSeq (mRNA)	NM_012079	NM_010046
RefSeq (protein)	NP_036211.2	NP_034176.1
Location (UCSC)	Chr 8: 144.31 – 144.33 Mb	Chr 15: 76.5 – 76.51 Mb
PubMed search	[1]	[2]
Wikidata

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Diacylglycerol O-acyltransferase 1 is an enzyme that in humans is encoded by the DGAT1 gene.^[3]

Function

This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases.^[4]

See also

• Diglyceride acyltransferase

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Diacylglycerol O-acyltransferase 1". Retrieved 2016-08-28.
4. Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV (2008). "Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis". Journal of Lipid Research. 49 (11): 2283–301. doi:10.1194/jlr.R800018-JLR200. PMC 3837458. PMID 18757836.

Further reading

• Ludwig EH, Mahley RW, Palaoglu E, Ozbayrakçi S, Balestra ME, Borecki IB, Innerarity TL, Farese RV (July 2002). "DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women". Clinical Genetics. 62 (1): 68–73. PMID 12123490.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.