DGKB

DGKB
Identifiers
Aliases	DGKB, DAGK2, DGK, DGK-BETA, diacylglycerol kinase beta
External IDs	MGI: 2442474 HomoloGene: 37875 GeneCards: DGKB
Genetically Related Diseases
type 2 diabetes mellitus, lymphoblastic leukemia[1]
Gene ontology Molecular function • transferase activity • nucleotide binding • calcium ion binding • ATP binding • metal ion binding • kinase activity • diacylglycerol kinase activity Cellular component • cytoplasm • plasma membrane Biological process • platelet activation • protein kinase C-activating G-protein coupled receptor signaling pathway • intracellular signal transduction • phosphorylation • glycerolipid metabolic process • carbohydrate phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1607	217480
Ensembl	ENSG00000136267	ENSMUSG00000036095
UniProt	Q9Y6T7	Q6NS52
RefSeq (mRNA)	NM_004080 NM_145695	NM_178681
RefSeq (protein)	NP_004071.1 NP_663733.1	NP_848796.2
Location (UCSC)	Chr 7: 14.15 – 14.97 Mb	Chr 12: 37.88 – 38.63 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene.^[4][5]

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.^[5]

References

1. "Diseases that are genetically associated with DGKB view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Goto K, Kondo H (Sep 1993). "Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons". Proc Natl Acad Sci U S A. 90 (16): 7598–602. doi:10.1073/pnas.90.16.7598. PMC 47189. PMID 7689223.
5. "Entrez Gene: DGKB diacylglycerol kinase, beta 90kDa".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Caricasole A, Bettini E, Sala C, et al. (2002). "Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties". J. Biol. Chem. 277 (7): 4790–6. doi:10.1074/jbc.M110249200. PMID 11719522.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.