DNAJB6

DNAJB6
Identifiers
Aliases DNAJB6, Dnajb6, Mrj, mDj4, DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, MSJ-1, DnaJ heat shock protein family (Hsp40) member B6
External IDs MGI: 1344381 HomoloGene: 38058 GeneCards: DNAJB6
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

10049

23950

Ensembl

ENSG00000105993

ENSMUSG00000029131

UniProt

O75190

O54946

RefSeq (mRNA)

NM_005494
NM_058246

NM_001037940
NM_001037941
NM_001127367
NM_011847

RefSeq (protein)

NP_005485.1
NP_490647.1

NP_001033029.1
NP_001120839.1
NP_035977.2

Location (UCSC) Chr 7: 157.34 – 157.42 Mb Chr 5: 29.74 – 29.82 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

DnaJ homolog subfamily B member 6 is a protein that in humans is encoded by the DNAJB6 gene.[3][4][5]

Function

This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.[5]

Interactions

DNAJB6 has been shown to interact with Keratin 18.[6] It has been also shown that the aggregation of Aβ42 (a process involved in e.g. Alzheimer's disease) is retarded by DNAJB6 in a concentration-dependent manner, extending to very low sub-stoichiometric molar ratios of chaperone to peptide.[7]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Seki N, Hattori A, Hayashi A, Kozuma S, Miyajima N, Saito T (June 1999). "Cloning, tissue expression, and chromosomal assignment of human MRJ gene for a member of the DNAJ protein family". J Hum Genet. 44 (3): 185–9. doi:10.1007/s100380050139. PMID 10319584.
  4. Pei L (March 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". J Biol Chem. 274 (5): 3151–8. doi:10.1074/jbc.274.5.3151. PMID 9915854.
  5. 1 2 "Entrez Gene: DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6".
  6. Izawa I, Nishizawa M, Ohtakara K, Ohtsuka K, Inada H, Inagaki M (2000). "Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein". J. Biol. Chem. 275 (44): 34521–7. doi:10.1074/jbc.M003492200. PMID 10954706.
  7. Månsson, C; Arosio, P; Hussein, R; Kampinga, H H; Hashem, R M; Boelens, W C; Emanuelsson, C (2014). "Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation.". J. Biol. Chem. 289 (45): 31066–76. doi:10.1074/jbc.M114.595124. PMC 4223311Freely accessible. PMID 25217638.

Further reading

External links

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