DOK5

DOK5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases DOK5, C20orf180, IRS-6, IRS6, docking protein 5
External IDs MGI: 1924079 HomoloGene: 10195 GeneCards: DOK5
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

55816

76829

Ensembl

ENSG00000101134

ENSMUSG00000027560

UniProt

Q9P104

Q91ZM9

RefSeq (mRNA)

NM_001294161
NM_018431
NM_177959

NM_001163686
NM_029761

RefSeq (protein)

NP_060901.2
NP_808874.1

NP_001157158.1
NP_084037.3

Location (UCSC) Chr 20: 54.48 – 54.65 Mb Chr 2: 170.73 – 170.88 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Docking protein 5 is a protein that in humans is encoded by the DOK5 gene.[3][4]

Function

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.[4]

Interactions

DOK5 has been shown to interact with RET proto-oncogene.[3][5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. 1 2 Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W (Jul 2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation". J Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770Freely accessible. PMID 11470823.
  4. 1 2 "Entrez Gene: DOK5 docking protein 5".
  5. Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.

Further reading


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