DOK5

DOK5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J0W
Identifiers
Aliases	DOK5, C20orf180, IRS-6, IRS6, docking protein 5
External IDs	MGI: 1924079 HomoloGene: 10195 GeneCards: DOK5
Gene ontology Molecular function • signal transducer activity, downstream of receptor • insulin receptor binding Cellular component • intracellular Biological process • regulation of neurotrophin TRK receptor signaling pathway • nervous system development • MAPK cascade • transmembrane receptor protein tyrosine kinase signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55816	76829
Ensembl	ENSG00000101134	ENSMUSG00000027560
UniProt	Q9P104	Q91ZM9
RefSeq (mRNA)	NM_001294161 NM_018431 NM_177959	NM_001163686 NM_029761
RefSeq (protein)	NP_060901.2 NP_808874.1	NP_001157158.1 NP_084037.3
Location (UCSC)	Chr 20: 54.48 – 54.65 Mb	Chr 2: 170.73 – 170.88 Mb
PubMed search	[1]	[2]
Wikidata

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Docking protein 5 is a protein that in humans is encoded by the DOK5 gene.^[3][4]

Function

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.^[4]

Interactions

DOK5 has been shown to interact with RET proto-oncogene.^[3][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W (Jul 2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation". J Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823.
4. "Entrez Gene: DOK5 docking protein 5".
5. Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.

Further reading

• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Shi N, Zhou W, Tang K, et al. (2003). "Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein". Acta Crystallogr. D. 58 (Pt 12): 2170–2. doi:10.1107/S090744490201644X. PMID 12454490.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Favre C, Gérard A, Clauzier E, et al. (2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. doi:10.1038/sj.gene.6363891. PMID 12595900.
• Cai D, Dhe-Paganon S, Melendez PA, et al. (2003). "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5". J. Biol. Chem. 278 (28): 25323–30. doi:10.1074/jbc.M212430200. PMID 12730241.
• Crowder RJ, Enomoto H, Yang M, et al. (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Shi L, Yue J, You Y, et al. (2007). "Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation". Cell. Signal. 18 (11): 1995–2003. doi:10.1016/j.cellsig.2006.03.007. PMID 16647839.