ERRFI1

ERRFI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RF9, 2RFD, 2RFE, 4I21, 4R3P, 4R3R, 4ZJV
Identifiers
Aliases	ERRFI1, GENE-33, MIG-6, MIG6, RALT, ERBB receptor feedback inhibitor 1
External IDs	MGI: 1921405 HomoloGene: 10344 GeneCards: ERRFI1
Gene ontology Molecular function • GTPase activator activity • SH3 domain binding • small GTPase binding • kinase binding • protein binding • protein kinase binding Cellular component • cytoplasm • cytosol • membrane • extrinsic component of cytoplasmic side of plasma membrane • plasma membrane • nucleus Biological process • negative regulation of interleukin-1 beta production • negative regulation of epidermal growth factor receptor signaling pathway • skin morphogenesis • negative regulation of protein autophosphorylation • response to stress • cellular response to platelet-derived growth factor stimulus • cellular response to dexamethasone stimulus • cellular response to epidermal growth factor stimulus • cellular hyperosmotic response • negative regulation of epidermal growth factor-activated receptor activity • negative regulation of tumor necrosis factor biosynthetic process • negative regulation of peptidyl-tyrosine phosphorylation • cellular response to insulin stimulus • negative regulation of ERK1 and ERK2 cascade • regulation of keratinocyte differentiation • lung alveolus development • lung vasculature development • lung epithelium development • regulation of type B pancreatic cell proliferation • negative regulation of collagen biosynthetic process • negative regulation of cardiac muscle hypertrophy in response to stress • positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54206	74155
Ensembl	ENSG00000116285	ENSMUSG00000028967
UniProt	Q9UJM3	Q99JZ7
RefSeq (mRNA)	NM_018948	NM_133753
RefSeq (protein)	NP_061821.1	NP_598514.1
Location (UCSC)	Chr 1: 8 – 8.03 Mb	Chr 4: 150.85 – 150.87 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.^{[3][4][5][6][7]}

MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).[supplied by OMIM]^[7]

Interactions

ERRFI1 has been shown to interact with Stratifin^[8] and CDC42.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM (Jul 2000). "Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress". J Biol Chem. 275 (23): 17838–17847. doi:10.1074/jbc.M909735199. PMID 10749885.
4. Chrapkiewicz NB, Davis CM, Chu DT, Caldwell CM, Granner DK (Oct 1989). "Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity". Nucleic Acids Res. 17 (16): 6651–6667. doi:10.1093/nar/17.16.6651. PMC 318357. PMID 2780291.
5. Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O (Sep 2002). "Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control". Oncogene. 21 (42): 6530–6539. doi:10.1038/sj.onc.1205823. PMID 12226756.
6. Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alema S, Benedetti P, Segatto O (Oct 2000). "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain". Mol Cell Biol. 20 (20): 7735–7750. doi:10.1128/MCB.20.20.7735-7750.2000. PMC 86354. PMID 11003669.
7. "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1".
8. Benzinger, Anne; Muster Nemone; Koch Heike B; Yates John R; Hermeking Heiko (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics. United States. 4 (6): 785–795. doi:10.1074/mcp.M500021-MCP200. ISSN 1535-9476. PMID 15778465.

Further reading

• Zhang YW, Vande Woude GF (2007). "Mig-6, signal transduction, stress response and cancer". Cell Cycle. 6 (5): 507–13. doi:10.4161/cc.6.5.3928. PMID 17351343.
• Wick M, Bürger C, Funk M, Müller R (1995). "Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation". Exp. Cell Res. 219 (2): 527–535. doi:10.1006/excr.1995.1261. PMID 7641805.
• Hackel PO, Gishizky M, Ullrich A (2002). "Mig-6 is a negative regulator of the epidermal growth factor receptor signal". Biol. Chem. 382 (12): 1649–1662. doi:10.1515/BC.2001.200. PMID 11843178.
• Tsunoda T, Inokuchi J, Baba I, et al. (2002). "A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6". Cancer Res. 62 (20): 5668–71. PMID 12384522.
• Saarikoski ST, Rivera SP, Hankinson O (2002). "Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia". FEBS Lett. 530 (1–3): 186–190. doi:10.1016/S0014-5793(02)03475-0. PMID 12387890.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Anastasi S, Fiorentino L, Fiorini M, et al. (2003). "Feedback inhibition by RALT controls signal output by the ErbB network". Oncogene. 22 (27): 4221–4234. doi:10.1038/sj.onc.1206516. PMID 12833145.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Xu D, Makkinje A, Kyriakis JM (2005). "Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function". J. Biol. Chem. 280 (4): 2924–2933. doi:10.1074/jbc.M408907200. PMID 15556944.
• Keeton AB, Messina JL (2005). "Modulation of Elk-dependent-transcription by Gene33". J. Cell. Biochem. 94 (6): 1190–1198. doi:10.1002/jcb.20370. PMID 15696545.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics. 4 (6): 785–795. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Anastasi S, Sala G, Huiping C, et al. (2005). "Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin". Oncogene. 24 (28): 4540–4548. doi:10.1038/sj.onc.1208658. PMID 15856022.
• Ballarò C, Ceccarelli S, Tiveron C, et al. (2006). "Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype". EMBO Rep. 6 (8): 755–761. doi:10.1038/sj.embor.7400458. PMC 1369136. PMID 16007071.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–321. doi:10.1038/nature04727. PMID 16710414.
• Zhang YW, Staal B, Su Y, et al. (2007). "Evidence that MIG-6 is a tumor-suppressor gene". Oncogene. 26 (2): 269–276. doi:10.1038/sj.onc.1209790. PMID 16819504.