Fixation (visual)

Microsaccades and Ocular Drifts

Fixation or visual fixation is the maintaining of the visual gaze on a single location. An animal can exhibit visual fixation if they possess a fovea in the anatomy of their eye. The fovea is typically located at the center of the retina and is the point of clearest vision. The species in which fixational eye movement has been found thus far include humans, primates, cats, rabbits, turtles, salamanders, and owls. Regular eye movement alternates between saccades and visual fixations, the notable exception being in smooth pursuit, controlled by a different neural substrate that appears to have developed for hunting prey. The term "fixation" can either be used to refer to the point in time and space of focus or the act of fixating. Fixation, in the act of fixating, is the point between any two saccades, during which the eyes are relatively stationary and virtually all visual input occurs. In the absence of retinal jitter, a laboratory condition known as retinal stabilization, perceptions tend to rapidly fade away.[1][2] To maintain visibility, the nervous system carries out a mechanism called fixational eye movement, which continuously stimulates neurons in the early visual areas of the brain responding to transient stimuli. There are three categories of fixational eye movements: microsaccades, ocular drifts, and ocular microtremor. Although the existence of these movements has been known since the 1950s, only recently their functions have started to become clear.[3][4]

Microsaccades

This image shows the tracking of eye movement during the viewing of a facial image. The lines display the saccadic and microsaccadic movement of the eye while looking at this face. The involuntary, micro-saccadic movement is not steady when the person's eyes are concentrated at the eyes of the woman, while the voluntary, saccadic movement goes around the periphery of the face once at any give point.

Microsaccades, also known as "flicks", are saccades, involuntarily, produced during the fixation periods. They are the largest and fastest of the fixational eye movements. Like saccades, microsaccades are usually binocular, and conjugate movements with comparable amplitudes and directions in both eyes. In the 1960s, scientists suggested the maximum amplitude for microsaccades should be 12 arcminutes to distinguish microsaccades and saccades.[5] However, recent studies have shown that microsaccades can certainly exceed this value.[6] Therefore, amplitude can no longer be used to distinguish microsaccades and saccades. The only way to distinguish microsaccades from saccades is by the time in which they happen: during fixation. Regular saccades are produced during the active exploration of the eye, during non-fixation tasks such as free viewing or visual search. However, microsaccades are distinguished from regular saccades because they are only produced during fixation tasks. The circularity of this definition has been the subject of ample criticism.[7]

Mechanism

Microsaccades have the ability to carry the retinal image from several dozen to several hundred photoreceptor widths. To maintain the visibility during fixation, they shift the retina image in a straight-line-fashion which overcomes adaption and generate neural responses to stationary stimuli in visual neurons.

Medical application

Though it is still controversial and highly debated, some neuroscientists believe that microsaccades are potentially important in neurological and ophthalmic diseases since they are strongly related to many features of visual perception, attention, and cognition.[8] Research on finding the purpose of microsaccades began in the 1990s. The development of non-invasive eye-movement-recording devices, the ability to record single-neuron activity in monkeys, and the use of computational processing power in the analysis of dynamic behavior lead to an advancement in microsaccade research.[9] Today, researching microsaccades is a central and quick-growing topic of interest in the visual, cognitive, and oculomotor neurosciences. Research on microsaccades includes investigating the perceptual effects of microsaccades, recording the neural responses they induce, and tracking the mechanisms behind their oculomotor generation. It has been shown that when fixation is not explicitly enforced as it often occurs in vision research experiments, microsaccades precisely shift gaze to nearby locations of interest .[10] This behavior compensates for non-uniform vision within the foveola.[11]

Some studies suggest the use of microsaccades as a diagnostic method for ADHD. The researchers measure the microsaccadic movement of the participants while they are taking the Test of Variables of Attention. The adults with no medication treatments tend to blink and make more microsaccades. However, there are also trials that fail to confirm this result. Therefore, it is still arguable to state whether measuring microsaccades may or may not be used as a foolproof diagnostic method for ADHD.[12]

Ocular drifts

Ocular drift is the fixational eye movement characterized by a smoother, slower, roaming motion of the eye when fixed on an object. The exact movement of ocular drift is often compared to Brownian motion, which is the random motion of a particle suspended in fluid as a result of its collision with the atoms and molecules that comprise that fluid. The movement can also be compared to a random walk, characterized by random and often erratic changes in direction.[13] Ocular drifts occur incessantly during intersaccadic fixation. Although the frequency of ocular drifts is usually lower than the frequency of ocular microtremors (from 20 to 40 Hz compared to from 40 to 100 Hz), it is problematic to distinguish occular drifts and occular microtremors in the range from 30 to 40 Hz.[14] Resolution of intersaccadic eye movements is technically challenging .[4]

Brownian Motion

Mechanism

The motion of ocular drift is related to the processing and encoding of space and time. It is also related to acquiring minute visual details of objects that are stationary, in order for these details to be further processed.[15] Recent results have shown that ocular drift reformats the input signal to the retina equalizing (whitening) spatial power at non-zero temporal frequencies across a broad spatial frequency range.[16]

Medical application

Ocular drifts were first found to be caused by an instability of the ocular motor system. However, more recent findings have shown that there are actually a number of suggested hypotheses as to why ocular drifts occur. First, ocular drifts can be caused by the uncontrollable random movements driven by neuronal or muscular noise, known as open loop scheme. Second, ocular drifts can occur to counter controlled motor variables, namely a motor control loop. Lastly, ocular drifts can be driven by retinal information, in a retino-motor control loop. When the head is not immobilized, as it usually happens in recordings of minute eye movements, ocular drifts compensate for the natural fixational instability of the head.[13]

Occular microtremors

Ocular microtremors (OMTs) are small, quick, and synchronized oscillations of the eyes occurring at frequencies in a range of 40 to 100 Hz, although they typically occur at around 90 Hz in the average healthy individual. They are characterized by their high frequency and minuscule amplitude of just a few arcseconds. Although the function of ocular microtremors is debatable and not fully known, they seem to play a role in processing of high spatial frequencies, which allows for perception of fine detail.[16][17][18] Recent studies show that ocular microtremors have become a promising tool for determining the level of consciousness in an individual, as well as the progression of some degenerative diseases including Parkinson's disease[19] and multiple sclerosis.[20]

Ocular microtremor tracing with burst sections underlined

Mechanism

Although originally thought to stem from spontaneous firing of motor units, the origin of ocular microtremors is now believed to be in the oculomotor nuclei in the reticular formation of the brainstem.[21] This new insight opened the possibility of using ocular tremors as a gauge for neuronal activity in that region of the central nervous system. More research must be done, but recent studies strongly suggest that decreased activity in the brainstem correlates with decreased frequency of OMTs.[22]

Medical application

Several methods of recording have been developed to observe these minuscule events, the most successful being the piezoelectric strain gauge method, which translates eye movement through a latex probe in contact with the eye leading to piezoelectric strain gauge. This method is practical in research but more practical adaptations of this technology have been developed by companies like Brainstem Biometrics[23] for use in a clinical setting for use in monitoring depth of anesthesia.[24]

See also

References

  1. ↑ Pritchard R.M., Heron W., & Hebb D.O. (1960). Visual Perception Approached by the Method of Stabilized Images. Canadian J. Psych., 14, 67–77.
  2. ↑ Coppola, D. & Purves, D. (1996). The Extraordinarily Rapid Disappearance of Entoptic Images. Proceedings of the National Academy of Sciences of the USA, 93, 8001–8004.
  3. ↑ M. Rucci and M. Poletti. Control and function of fixational eye movements. Annual Review of Vision Science, 1:499–518, 2015.
  4. 1 2 Rucci, Michele; McGraw, Paul V.; Krauzlis, Richard J. (2016-01-01). "Fixational eye movements and perception". Vision Research. 118: 1–4. doi:10.1016/j.visres.2015.12.001. ISSN 1878-5646. PMID 26686666.
  5. ↑ Collewijn, Han; Kowler, Eileen (2008-01-01). "The significance of microsaccades for vision and oculomotor control". Journal of Vision. 8 (14): 20.1–21. doi:10.1167/8.14.20. ISSN 1534-7362. PMC 3522523Freely accessible. PMID 19146321.
  6. ↑ Troncoso, Xoana G.; Macknik, Stephen L.; Martinez-Conde, Susana (2008-01-01). "Microsaccades counteract perceptual filling-in". Journal of Vision. 8 (14): 15.1–9. doi:10.1167/8.14.15. ISSN 1534-7362. PMID 19146316.
  7. ↑ M. Poletti and M. Rucci. A compact field guide to the study of microsaccades: Challenges and functions. Vision Research, 118, 83--97, 2016.
  8. ↑ Martinez-Conde, Susana; Macknik, Stephen L.; Troncoso, Xoana G.; Hubel, David H. (2009-09-01). "Microsaccades: a neurophysiological analysis". Trends in Neurosciences. 32 (9): 463–475. doi:10.1016/j.tins.2009.05.006. ISSN 1878-108X. PMID 19716186.
  9. ↑ Martinez-Conde, S.; Macknik, S. L.; Hubel, D. H. (2000-03-01). "Microsaccadic eye movements and firing of single cells in the striate cortex of macaque monkeys". Nature Neuroscience. 3 (3): 251–258. doi:10.1038/72961. ISSN 1097-6256. PMID 10700257.
  10. ↑ H.-K. Ko, M. Poletti, and M. Rucci. Microsaccades precisely relocate gaze in a high visual acuity task. Nat. Neurosci., 13(12):1549–1553, 2010.
  11. ↑ M. Poletti, C. Listorti, and M. Rucci. Microscopic eye movements compensate for nonhomogeneous vision within the fovea. Curr. Biol., 23(17):1691–1695, 2013.
  12. ↑ Fried, Moshe; Tsitsiashvili, Eteri; Bonneh, Yoram S.; Sterkin, Anna; Wygnanski-Jaffe, Tamara; Epstein, Tamir; Polat, Uri (2014-08-01). "ADHD subjects fail to suppress eye blinks and microsaccades while anticipating visual stimuli but recover with medication". Vision Research. 101: 62–72. doi:10.1016/j.visres.2014.05.004. ISSN 1878-5646. PMID 24863585.
  13. 1 2 M. Poletti, M. Aytekin, M. Rucci, "Head-eye coordination at a microscopic scale." Current Biology, 25, 3253-3259, 2015.
  14. ↑ Ahissar, Ehud; Arieli, Amos; Fried, Moshe; Bonneh, Yoram (2016-01-01). "On the possible roles of microsaccades and drifts in visual perception". Vision Research. 118: 25–30. doi:10.1016/j.visres.2014.12.004. ISSN 1878-5646. PMID 25535005.
  15. ↑ Kuang, Xutao; Poletti, Martina; Victor, Jonathan D.; Rucci, Michele (2012-03-20). "Temporal encoding of spatial information during active visual fixation". Current biology: CB. 22 (6): 510–514. doi:10.1016/j.cub.2012.01.050. ISSN 1879-0445. PMC 3332095Freely accessible. PMID 22342751.
  16. 1 2 M. Rucci and J. D. Victor. The unsteady eye: an information processing stage, not a bug. Trends in Neurosciences, 38:195–206, 2015.
  17. ↑ M. Rucci, R. Iovin, M. Poletti, and F. Santini (2007), Miniature Eye Movements Enhance Fine Spatial Detail, Nature. 447(7146), 851-854.
  18. ↑ Otero-Millan, Jorge; Macknik, Stephen L.; Martinez-Conde, Susana (2014-01-01). "Fixational eye movements and binocular vision". Frontiers in Integrative Neuroscience. 8: 52. doi:10.3389/fnint.2014.00052. ISSN 1662-5145. PMC 4083562Freely accessible. PMID 25071480.
  19. ↑ Bolger, C.; Bojanic, S.; Sheahan, N. F.; Coakley, D.; Malone, J. F. (1999-04-01). "Ocular microtremor in patients with idiopathic Parkinson's disease". Journal of Neurology, Neurosurgery, and Psychiatry. 66 (4): 528–531. doi:10.1136/jnnp.66.4.528. ISSN 0022-3050. PMC 1736284Freely accessible. PMID 10201430.
  20. ↑ Bolger, C.; Bojanic, S.; Sheahan, N.; Malone, J.; Hutchinson, M.; Coakley, D. (2000-05-01). "Ocular microtremor (OMT): a new neurophysiological approach to multiple sclerosis". Journal of Neurology, Neurosurgery, and Psychiatry. 68 (5): 639–642. doi:10.1136/jnnp.68.5.639. ISSN 0022-3050. PMC 1736931Freely accessible. PMID 10766897.
  21. ↑ Spauschus, A.; Marsden, J.; Halliday, D. M.; Rosenberg, J. R.; Brown, P. (1999-06-01). "The origin of ocular microtremor in man". Experimental Brain Research. 126 (4): 556–562. doi:10.1007/s002210050764. ISSN 0014-4819. PMID 10422719.
  22. ↑ Bojanic, S.; Simpson, T.; Bolger, C. (2001-04-01). "Ocular microtremor: a tool for measuring depth of anaesthesia?". British Journal of Anaesthesia. 86 (4): 519–522. doi:10.1093/bja/86.4.519. ISSN 0007-0912. PMID 11573625.
  23. ↑ "Tremor Monitor Unit - Brainstem Biometrics". Brainstem Biometrics. Retrieved 2016-04-08.
  24. ↑ Bengi, H.; Thomas, J. G. (1968-03-01). "Three electronic methods for recording ocular tremor". Medical & Biological Engineering. 6 (2): 171–179. doi:10.1007/bf02474271. ISSN 0025-696X. PMID 5651798.
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