GAL3ST1

GAL3ST1
Identifiers
Aliases	GAL3ST1, CST, galactose-3-O-sulfotransferase 1
External IDs	MGI: 1858277 HomoloGene: 3574 GeneCards: GAL3ST1
Gene ontology Molecular function • transferase activity • sulfotransferase activity • galactosylceramide sulfotransferase activity Cellular component • integral component of membrane • Golgi membrane • Golgi apparatus • integral component of plasma membrane • membrane Biological process • glycolipid biosynthetic process • myelination • galactosylceramide biosynthetic process • protein N-linked glycosylation • spermatogenesis • sphingolipid metabolic process • lipid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9514	53897
Ensembl	ENSG00000128242	ENSMUSG00000049721
UniProt	Q99999	Q9JHE4
RefSeq (mRNA)	NM_004861 NM_001318103 NM_001318104 NM_001318105 NM_001318106 NM_001318107 NM_001318108 NM_001318109 NM_001318110 NM_001318111 NM_001318112 NM_001318113 NM_001318114 NM_001318115 NM_001318116	NM_001177691 NM_001177703 NM_016922
RefSeq (protein)	NP_004852.1 NP_001305032.1 NP_001305033.1 NP_001305034.1 NP_001305035.1 NP_001305036.1 NP_001305037.1 NP_001305038.1 NP_001305039.1 NP_001305040.1 NP_001305041.1 NP_001305042.1 NP_001305043.1 NP_001305044.1 NP_001305045.1	NP_001171162.1 NP_001171174.1 NP_058618.2
Location (UCSC)	Chr 22: 30.55 – 30.57 Mb	Chr 11: 3.98 – 4 Mb
PubMed search	[1]	[2]
Wikidata

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Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.^[3][4][5]

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. Jan 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
4. Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (Apr 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". J Biol Chem. 272 (8): 4864–8. doi:10.1074/jbc.272.8.4864. PMID 9030544.
5. "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1".

Further reading

• Siegrist HP, Jutzi H, Steck AJ, et al. (1977). "Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures". Biochim. Biophys. Acta. 489 (1): 58–63. doi:10.1016/0005-2760(77)90231-4. PMID 911873.
• Stein C, Gieselmann V, Kreysing J, et al. (1989). "Cloning and expression of human arylsulfatase A". J. Biol. Chem. 264 (2): 1252–9. PMID 2562955.
• Fleischer B, Zambrano F (1973). "Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney". Biochem. Biophys. Res. Commun. 52 (3): 951–8. doi:10.1016/0006-291X(73)91029-2. PMID 4710574.
• Farrell DF, McKhann GM (1971). "Characterization of cerebroside sulfotransferase from rat brain". J. Biol. Chem. 246 (15): 4694–702. PMID 5562350.
• Costantino-Ceccarini E, Waehneldt TV, Ginalski H, et al. (1982). "Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development". Neurochem. Res. 7 (1): 1–12. doi:10.1007/BF00965064. PMID 6280086.
• Benjamins JA, Hadden T, Skoff RP (1982). "Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain". J. Neurochem. 38 (1): 233–41. doi:10.1111/j.1471-4159.1982.tb10875.x. PMID 6955451.
• Honke K, Yamane M, Ishii A, et al. (1996). "Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells". J. Biochem. 119 (3): 421–7. doi:10.1093/oxfordjournals.jbchem.a021258. PMID 8830034.
• Tsuda M, Egashira M, Niikawa N, et al. (2000). "Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene". Eur. J. Biochem. 267 (9): 2672–9. doi:10.1046/j.1432-1327.2000.01281.x. PMID 10785389.
• Eckhardt M, Fewou SN, Ackermann I, Gieselmann V (2002). "N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase". Biochem. J. 368 (Pt 1): 317–24. doi:10.1042/BJ20020946. PMC 1222978. PMID 12175333.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.