GCLM

For the post-nomial, see Legion of Merit (Rhodesia).
GCLM
Identifiers
Aliases GCLM, GLCLR, glutamate-cysteine ligase modifier subunit
External IDs MGI: 104995 HomoloGene: 1557 GeneCards: GCLM
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

2730

14630

Ensembl

ENSG00000023909

ENSMUSG00000028124

UniProt

P48507

O09172

RefSeq (mRNA)

NM_001308253
NM_002061

NM_008129

RefSeq (protein)

NP_001295182.1
NP_002052.1

NP_032155.1

Location (UCSC) Chr 1: 93.89 – 93.91 Mb Chr 3: 122.25 – 122.27 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Glutamate-cysteine ligase regulatory subunit is an enzyme that in humans is encoded by the GCLM gene.[3][4]

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subuit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Gipp JJ, Bailey HH, Mulcahy RT (Feb 1995). "Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues". Biochem Biophys Res Commun. 206 (2): 584–9. doi:10.1006/bbrc.1995.1083. PMID 7826375.
  4. 1 2 "Entrez Gene: GCLM glutamate-cysteine ligase, modifier subunit".

Further reading


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