GPSM1

GPSM1
Identifiers
Aliases GPSM1, AGS3, G-protein signaling modulator 1
External IDs MGI: 1915089 HomoloGene: 16987 GeneCards: GPSM1
Genetically Related Diseases
type 2 diabetes mellitus[1]
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

26086

67839

Ensembl

ENSG00000160360

ENSMUSG00000026930

UniProt

Q86YR5

Q6IR34

RefSeq (mRNA)

NM_001145638
NM_001145639
NM_001200003
NM_015597

NM_001199146
NM_001199147
NM_153410

RefSeq (protein)

NP_001139110.2
NP_001139111.1
NP_001186932.1
NP_056412.5

NP_001186075.1
NP_001186076.1
NP_700459.2

Location (UCSC) Chr 9: 136.33 – 136.36 Mb Chr 2: 26.32 – 26.35 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

G-protein-signaling modulator 1 is a protein that in humans is encoded by the GPSM1 gene.[4][5][6]

G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001).[supplied by OMIM][6]

References

  1. "Diseases that are genetically associated with GPSM1 view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. Pizzinat N, Takesono A, Lanier SM (May 2001). "Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains". J Biol Chem. 276 (20): 16601–10. doi:10.1074/jbc.M007573200. PMID 11278352.
  5. Peterson YK, Bernard ML, Ma H, Hazard S III, Graber SG, Lanier SM (Nov 2000). "Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3". J Biol Chem. 275 (43): 33193–6. doi:10.1074/jbc.C000509200. PMID 10969064.
  6. 1 2 "Entrez Gene: GPSM1 G-protein signalling modulator 1 (AGS3-like, C. elegans)".

Further reading


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