Syncytin-2

ERVFRD-1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1Y4M
Identifiers
Aliases	ERVFRD-1, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD, ERVFRD-1, endogenous retrovirus group FRD member 1
External IDs	MGI: 3045308 HomoloGene: 86779 GeneCards: ERVFRD-1
Orthologs
Species	Human	Mouse
Entrez	405754	239167
Ensembl	ENSG00000244476	ENSMUSG00000047977
UniProt	P60508	n/a
RefSeq (mRNA)	NM_207582	NM_173420
RefSeq (protein)	NP_997465.1	n/a
Location (UCSC)	Chr 6: 11.1 – 11.11 Mb	Chr 14: 69.29 – 69.29 Mb
PubMed search	[1]	[2]
Wikidata

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Syncytin-2 also known as endogenous retrovirus group FRD member 1 is a protein that in humans is encoded by the ERVFRD-1 gene.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: HERV-FRD HERV-FRD provirus ancestral Env polyprotein".

Further reading

• de Parseval N, Lazar V, Casella JF, Benit L, Heidmann T (October 2003). "Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins". Journal of Virology. 77 (19): 10414–22. doi:10.1128/JVI.77.19.10414-10422.2003. PMC 228468. PMID 12970426.
• Blaise S, de Parseval N, Bénit L, Heidmann T (October 2003). "Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution". Proceedings of the National Academy of Sciences of the United States of America. 100 (22): 13013–8. doi:10.1073/pnas.2132646100. PMC 240736. PMID 14557543.
• Blaise S, Ruggieri A, Dewannieux M, Cosset FL, Heidmann T (January 2004). "Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simians". Journal of Virology. 78 (2): 1050–4. doi:10.1128/JVI.78.2.1050-1054.2004. PMC 368808. PMID 14694139.
• Renard M, Varela PF, Letzelter C, Duquerroy S, Rey FA, Heidmann T (October 2005). "Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates". Journal of Molecular Biology. 352 (5): 1029–34. doi:10.1016/j.jmb.2005.07.058. PMID 16140326.
• Malassiné A, Blaise S, Handschuh K, Lalucque H, Dupressoir A, Evain-Brion D, Heidmann T (2007). "Expression of the fusogenic HERV-FRD Env glycoprotein (syncytin 2) in human placenta is restricted to villous cytotrophoblastic cells". Placenta. 28 (2-3): 185–91. doi:10.1016/j.placenta.2006.03.001. PMID 16714059.