HEXIM2

HEXIM2
Identifiers
Aliases	HEXIM2, L3, hexamethylene bisacetamide inducible 2
External IDs	MGI: 1918309 HomoloGene: 16946 GeneCards: HEXIM2
Gene ontology Molecular function • cyclin-dependent protein serine/threonine kinase inhibitor activity • snRNA binding • protein binding • 7SK snRNA binding Cellular component • cytoplasm • nucleus • nucleoplasm Biological process • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • negative regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of protein serine/threonine kinase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	124790	71059
Ensembl	ENSG00000168517	ENSMUSG00000043372
UniProt	Q96MH2	Q3TVI4
RefSeq (mRNA)	NM_001303436 NM_001303437 NM_001303438 NM_001303439 NM_001303440 NM_001303441 NM_001303442 NM_001303443 NM_001303444 NM_144608	NM_001130515 NM_001130516 NM_027658
RefSeq (protein)	NP_001290365.1 NP_001290366.1 NP_001290367.1 NP_001290368.1 NP_001290369.1 NP_001290370.1 NP_001290371.1 NP_001290372.1 NP_001290373.1 NP_653209.1	NP_001123987.1 NP_001123988.1 NP_081934.1
Location (UCSC)	Chr 17: 45.16 – 45.17 Mb	Chr 11: 103.13 – 103.14 Mb
PubMed search	[1]	[2]
Wikidata

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View/Edit Mouse

Protein HEXIM2 is a protein that in humans is encoded by the HEXIM2 gene.^[3][4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O (Jun 2003). "MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner". Mol Cell Biol. 23 (14): 4859–69. doi:10.1128/MCB.23.14.4859-4869.2003. PMC 162212. PMID 12832472.
4. "Entrez Gene: HEXIM2 hexamthylene bis-acetamide inducible 2".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Petroziello J, Yamane A, Westendorf L, et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer.". Oncogene. 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068.
• Yik JH, Chen R, Pezda AC, Zhou Q (2005). "Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription.". J. Biol. Chem. 280 (16): 16368–76. doi:10.1074/jbc.M500912200. PMID 15713661.
• Byers SA, Price JP, Cooper JJ, et al. (2005). "HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK.". J. Biol. Chem. 280 (16): 16360–7. doi:10.1074/jbc.M500424200. PMID 15713662.
• Li Q, Price JP, Byers SA, et al. (2005). "Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.". J. Biol. Chem. 280 (31): 28819–26. doi:10.1074/jbc.M502712200. PMID 15965233.
• Fraldi A, Varrone F, Napolitano G, et al. (2006). "Inhibition of Tat activity by the HEXIM1 protein.". Retrovirology. 2 (1): 42. doi:10.1186/1742-4690-2-42. PMC 1183248. PMID 15992410.