HIST1H4B

HIST1H4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX
Identifiers
Aliases	HIST1H4B, H4/I, H4FI, histone cluster 1, H4b
External IDs	MGI: 2448443 HomoloGene: 134493 GeneCards: HIST1H4B
Gene ontology Molecular function • DNA binding • protein domain specific binding • histone binding • protein binding • protein heterodimerization activity • poly(A) RNA binding Cellular component • membrane • chromosome • protein complex • nucleoplasm • extracellular region • nuclear chromosome • nucleosome • extracellular exosome • nucleus • nuclear chromosome, telomeric region • extracellular matrix Biological process • telomere organization • cellular protein metabolic process • positive regulation of gene expression, epigenetic • protein heterotetramerization • negative regulation of megakaryocyte differentiation • CENP-A containing nucleosome assembly • DNA replication-dependent nucleosome assembly • chromatin silencing at rDNA • negative regulation of gene expression, epigenetic • DNA-templated transcription, initiation • DNA replication-independent nucleosome assembly • gene silencing by RNA • double-strand break repair via nonhomologous end joining • beta-catenin-TCF complex assembly • nucleosome assembly • telomere capping Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8366	320332
Ensembl	ENSG00000278705	ENSMUSG00000096010
UniProt	P62805	P62806
RefSeq (mRNA)	NM_003544	NM_175652
RefSeq (protein)	NP_001029249.1 NP_003486.1 NP_003529.1 NP_003530.1 NP_003531.1 NP_003532.1 NP_003533.1 NP_003534.1 NP_003535.1 NP_003536.1 NP_003537.1 NP_003539.1 NP_068803.1 NP_778224.1	NP_001182350.1 NP_291074.1 NP_694813.1 NP_783583.1 NP_783585.1 NP_783586.1 NP_783587.1 NP_783588.1 NP_835499.1 NP_835500.1 NP_835515.1 NP_835582.1 NP_835583.1
Location (UCSC)	Chr 6: 26.03 – 26.03 Mb	Chr 6: 136.8 – 136.8 Mb
PubMed search	[1]	[2]
Wikidata

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Histone H4 is a protein that in humans is encoded by the HIST1H4B gene.^[3][4][5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 147 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–322. doi:10.1006/geno.1996.4592. PMID 9119399.
4. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
5. "Entrez Gene: HIST1H4B histone cluster 1, H4b".

Further reading

• Albig W, Kardalinou E, Drabent B, et al. (1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–948. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.
• Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–294. doi:10.1007/s004390050630. PMID 9439656.
• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
• Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–295. doi:10.1006/viro.2000.0593. PMID 11080476.
• Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–326. doi:10.1006/viro.2001.1129. PMID 11689053.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–6561. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.