HIST1H4J

HIST1H4J
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX
Identifiers
Aliases	HIST1H4J, H4/e, H4F2iv, H4FE, dJ160A22.2, histone cluster 1, H4j
External IDs	MGI: 2448425 HomoloGene: 134492 GeneCards: HIST1H4J
Gene ontology Molecular function • DNA binding • protein domain specific binding • histone binding • protein binding • protein heterodimerization activity • poly(A) RNA binding Cellular component • membrane • chromosome • protein complex • nucleoplasm • extracellular region • nuclear chromosome • nucleosome • extracellular exosome • nucleus • nuclear chromosome, telomeric region • extracellular matrix Biological process • telomere organization • cellular protein metabolic process • positive regulation of gene expression, epigenetic • protein heterotetramerization • negative regulation of megakaryocyte differentiation • CENP-A containing nucleosome assembly • DNA replication-dependent nucleosome assembly • chromatin silencing at rDNA • negative regulation of gene expression, epigenetic • DNA-templated transcription, initiation • DNA replication-independent nucleosome assembly • gene silencing by RNA • double-strand break repair via nonhomologous end joining • beta-catenin-TCF complex assembly • nucleosome assembly • telomere capping Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8363	319157
Ensembl	ENSG00000197238	ENSMUSG00000069274
UniProt	P62805	n/a
RefSeq (mRNA)	NM_021968	NM_175655
RefSeq (protein)	NP_001029249.1 NP_003486.1 NP_003529.1 NP_003530.1 NP_003531.1 NP_003532.1 NP_003533.1 NP_003534.1 NP_003535.1 NP_003536.1 NP_003537.1 NP_003539.1 NP_068803.1 NP_778224.1	n/a
Location (UCSC)	Chr 6: 27.82 – 27.82 Mb	Chr 13: 23.55 – 23.55 Mb
PubMed search	[1]	[2]
Wikidata

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Histone cluster 1, H4j is a protein that in humans is encoded by the HIST1H4J gene.^[3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008].^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Histone cluster 1, H4j". Retrieved 2012-03-12.

Further reading

• Deng, L.; De La Fuente, C.; Fu, P.; Wang, L.; Donnelly, R.; Wade, J. D.; Lambert, P.; Li, H.; Lee, C. G.; Kashanchi, F. (2000). "Acetylation of HIV-1 Tat by CBP/P300 Increases Transcription of Integrated HIV-1 Genome and Enhances Binding to Core Histones". Virology. 277 (2): 278–295. doi:10.1006/viro.2000.0593. PMID 11080476.
• Deng, L.; Wang, D.; De La Fuente, C.; Wang, L.; Li, H.; Lee, C. G.; Donnelly, R.; Wade, J. D.; Lambert, P.; Kashanchi, F. (2001). "Enhancement of the p300 HAT Activity by HIV-1 Tat on Chromatin DNA". Virology. 289 (2): 312–326. doi:10.1006/viro.2001.1129. PMID 11689053.
• Marzluff, W. F.; Gongidi, P.; Woods, K. R.; Jin, J.; Maltais, L. J. (2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
• Lusic, M.; Marcello, A.; Cereseto, A.; Giacca, M. (2003). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". The EMBO Journal. 22 (24): 6550–6561. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
• Heintz, N.; Zernik, M.; Roeder, R. G. (1981). "The structure of the human histone genes: Clustered but not tandemly repeated". Cell. 24 (3): 661–668. doi:10.1016/0092-8674(81)90092-1. PMID 6265100.
• Albig, W.; Doenecke, D. (1997). "The human histone gene cluster at the D6S105 locus". Human Genetics. 101 (3): 284–294. doi:10.1007/s004390050630. PMID 9439656.
• El Kharroubi, A.; Piras, G.; Zensen, R.; Martin, M. A. (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Molecular and Cellular Biology. 18 (5): 2535–2544. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.