HS2ST1

HS2ST1
Identifiers
Aliases	HS2ST1, dJ604K5.2, heparan sulfate 2-O-sulfotransferase 1
External IDs	MGI: 1346049 HomoloGene: 8025 GeneCards: HS2ST1
Gene ontology Molecular function • transferase activity • sulfotransferase activity • heparan sulfate 2-O-sulfotransferase activity Cellular component • integral component of membrane • Golgi membrane • Golgi apparatus • membrane Biological process • glycosaminoglycan biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9653	23908
Ensembl	ENSG00000153936	ENSMUSG00000040151
UniProt	Q7LGA3	Q8R3H7
RefSeq (mRNA)	NM_012262 NM_001134492	NM_011828
RefSeq (protein)	NP_001127964.1 NP_036394.1	NP_035958.3
Location (UCSC)	Chr 1: 86.91 – 87.11 Mb	Chr 3: 144.43 – 144.57 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.^[3][4]

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes heparan sulfate 2-O-sulfotransferase, a member of the heparan sulfate biosynthetic enzyme family. This family member transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
4. "Entrez Gene: HS2ST1 heparan sulfate 2-O-sulfotransferase 1".

Further reading

• Muramatsu T (2000). "Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting". J. Biochem. 127 (2): 171–6. doi:10.1093/oxfordjournals.jbchem.a022590. PMID 10731680.
• Rong J, Habuchi H, Kimata K, et al. (2000). "Expression of heparan sulphate L-iduronyl 2-O-sulphotransferase in human kidney 293 cells results in increased D-glucuronyl 2-O-sulphation". Biochem. J. 346 (2): 463–8. doi:10.1042/0264-6021:3460463. PMC 1220874. PMID 10677367.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Aquino RS, Landeira-Fernandez AM, Valente AP, et al. (2005). "Occurrence of sulfated galactans in marine angiosperms: evolutionary implications". Glycobiology. 15 (1): 11–20. doi:10.1093/glycob/cwh138. PMID 15317737.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Xu D, Song D, Pedersen LC, Liu J (2007). "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase". J. Biol. Chem. 282 (11): 8356–67. doi:10.1074/jbc.M608062200. PMID 17227754.