Helicase–primase complex
A helicase–primase complex (also helicase-primase, Hel/Prim, H-P or H/P) is a complex of enzymes including DNA helicase and DNA primase. A helicase-primase associated factor protein may also be present.[1]
The complex is used by herpesviruses in which it is responsible for lytic DNA virus replication.[2][3][4] In many dsDNA viruses primase and helicase are fused into a single polypeptide, so that the primase and helicase domains correspond to the N-terminal and C-terminal parts of the protein, respectively.[5] A helicase-primase inhibitor (HPI) is a drug that blocks this action through acting as an enzyme inhibitor.
List of H-P by virus name
List of H-P inhibitors
- BAY 57-1293, AIC316 or pritelivir
- BILS 22 BS[6]
- ASP2151 (amenamevir) [6]
- T157602[6]
See also
- Viral terminase
References
- ↑ Encyclopedia of toxicology: Dib-L], Volume 2 edited by Philip Wexler, Bruce D. Anderson
- 1 2 "Production and characterisation of Epstein–Barr virus helicase–primase complex and its accessory protein BBLF2/3". Virus Genes. 51: 171–181. doi:10.1007/s11262-015-1233-6.
- ↑ Hans-Georg Kräusslich; Ralf Bartenschlager (2 December 2008). Antiviral Strategies. Springer Science & Business Media. pp. 162–8. ISBN 978-3-540-79086-0.
- ↑ Herpes DNA Synthesis: Initiation of New DNA Strands and Discrimination Between Right and Wrong Bases by the Polymerase. ProQuest. 2008. pp. 2–12. ISBN 978-0-549-67366-8.
- ↑ Kazlauskas D, Krupovic M, Venclovas Č (2016). "The logic of DNA replication in double-stranded DNA viruses: insights from global analysis of viral genomes" (PDF). Nucleic Acids Res. 44: pii: gkw322. doi:10.1093/nar/gkw322. PMC 4889955
. PMID 27112572. - 1 2 3 Weller SK, Kuchta RD (2013). "The DNA helicase–primase complex as a target for herpes viral infection". Expert Opinion on Therapeutic Targets. 17: 1119–32. doi:10.1517/14728222.2013.827663. PMC 4098783. PMID 23930666.
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