IGHG3

IGHG3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4ZNC
Identifiers
Aliases	IGHG3, IgG3, immunoglobulin heavy constant gamma 3 (G3m marker)
External IDs	GeneCards: IGHG3
Gene ontology Molecular function • immunoglobulin receptor binding • antigen binding • serine-type endopeptidase activity Cellular component • extracellular space • extracellular region • blood microparticle • extracellular exosome • external side of plasma membrane • immunoglobulin complex, circulating Biological process • B cell receptor signaling pathway • phagocytosis, recognition • positive regulation of B cell activation • complement activation • retina homeostasis • phagocytosis, engulfment • defense response to bacterium • Fc-gamma receptor signaling pathway involved in phagocytosis • complement activation, classical pathway • innate immune response • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3502	n/a
Ensembl	n/a	n/a
UniProt	P01860	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Ig gamma-3 chain C region is a protein that in humans is encoded by the IGHG3 gene.^[2][3]

References

1. "Human PubMed Reference:".
2. Alexander A, Steinmetz M, Barritault D, Frangione B, Franklin EC, Hood L, Buxbaum JN (Sep 1982). "gamma Heavy chain disease in man: cDNA sequence supports partial gene deletion model". Proc Natl Acad Sci U S A. 79 (10): 3260–4. doi:10.1073/pnas.79.10.3260. PMC 346395. PMID 6808505.
3. "Entrez Gene: IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)".

Further reading

• Michaelsen TE, Frangione B, Franklin EC (1977). "Primary structure of the "hinge" region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit.". J. Biol. Chem. 252 (3): 883–9. PMID 402363.
• Wolfenstein-Todel C, Frangione B, Prelli F, Franklin EC (1976). "The amino acid sequence of "heavy chain disease" protein ZUC. Structure of the Fc fragment of immunoglobulin G3.". Biochem. Biophys. Res. Commun. 71 (4): 907–14. doi:10.1016/0006-291X(76)90741-5. PMID 823945.
• Huck S, Fort P, Crawford DH, et al. (1986). "Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes.". Nucleic Acids Res. 14 (4): 1779–89. doi:10.1093/nar/14.4.1779. PMC 339572. PMID 3081877.
• Frangione B, Rosenwasser E, Prelli F, Franklin EC (1980). "Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis.". Biochemistry. 19 (18): 4304–8. doi:10.1021/bi00559a024. PMID 6774747.
• Lewis AP, Lemon SM, Barber KA, et al. (1993). "Rescue, expression, and analysis of a neutralizing human anti-hepatitis A virus monoclonal antibody.". J. Immunol. 151 (5): 2829–38. PMID 8395549.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.