IGKC

IGKC
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1A4J, 1A4K, 1CLY, 1D5B, 1D5I, 1D6V, 1DFB, 1GAF, 1HEZ, 1HKL, 1HZH, 1I7Z, 1MIM, 1N0X, 1OM3, 1OP3, 1OP5, 1UCB, 2NY7, 2RFX, 3IU3, 3O11, 3RU8, 3U0W, 3VH8, 3WUW, 3X11, 3X12, 4HIX, 4NM4, 4NM8, 4XMP, 4XNY, 4XNZ, 4XXD, 4YDV, 4D3C, 5B38, 5B39
Identifiers
Aliases	IGKC, HCAK1, IGKCD, Km, immunoglobulin kappa constant
External IDs	GeneCards: IGKC
Gene ontology Molecular function • antigen binding • immunoglobulin receptor binding • serine-type endopeptidase activity Cellular component • blood microparticle • plasma membrane • immunoglobulin complex, circulating • extracellular space • extracellular region • extracellular exosome • external side of plasma membrane Biological process • B cell receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • complement activation • receptor-mediated endocytosis • Fc-epsilon receptor signaling pathway • phagocytosis, engulfment • retina homeostasis • defense response to bacterium • immune response • complement activation, classical pathway • regulation of immune response • phagocytosis, recognition • positive regulation of B cell activation • innate immune response • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3514	n/a
Ensembl	n/a	n/a
UniProt	P01834	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes the constant domain of kappa-type light chains for antibodies.^[2] It is found on chromosome 2, in humans, within the Immunoglobulin kappa locus, IGK@.

References

1. "Human PubMed Reference:".
2. "Entrez Gene: IGKC immunoglobulin kappa constant".

Further reading

• Brady RL, Edwards DJ, Hubbard RE, et al. (1992). "Crystal structure of a chimeric Fab' fragment of an antibody binding tumour cells". J. Mol. Biol. 227 (1): 253–64. doi:10.1016/0022-2836(92)90695-G. PMID 1522589.
• Titani K, Shinoda T, Putnam FW (1969). "The amino acid sequence of a kappa type Bence-Jones protein. 3. The complete sequence and the location of the disulfide bridges". J. Biol. Chem. 244 (13): 3550–60. PMID 4893682.
• Gall WE, Edelman GM (1971). "The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds". Biochemistry. 9 (16): 3188–96. doi:10.1021/bi00818a011. PMID 4923144.
• Suter L, Barnikol HU, Watanabe S, Hilschmann N (1972). "[Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The complete amino acid sequence and its significance for the mechanism of antibody production]". Hoppe-Seyler's Z. Physiol. Chem. 353 (2): 189–208. PMID 5027703.
• Kohler H, Shimizu A, Paul C, Putnam FW (1970). "Macroglobulin structure: variable sequence of light and heavy chains". Science. 169 (3940): 56–9. doi:10.1126/science.169.3940.56. PMID 5447531.
• Gottlieb PD, Cunningham BA, Rutishauser U, Edelman GM (1971). "The covalent structure of a human gamma G-immunoglobulin. VI. Amino acid sequence of the light chain". Biochemistry. 9 (16): 3155–61. doi:10.1021/bi00818a007. PMID 5489770.
• Hilschmann N (1968). "[The complete amino acid sequence of Bence Jones protein Cum (kappa-type)]". Hoppe-Seyler's Z. Physiol. Chem. 348 (12): 1718–22. PMID 5586923.
• Klobeck HG, Combriato G, Zachau HG (1984). "Immunoglobulin genes of the kappa light chain type from two human lymphoid cell lines are closely related". Nucleic Acids Res. 12 (18): 6995–7006. doi:10.1093/nar/12.18.6995. PMC 320138. PMID 6091049.
• Hieter PA, Maizel JV, Leder P (1982). "Evolution of human immunoglobulin kappa J region genes". J. Biol. Chem. 257 (3): 1516–22. PMID 6276389.
• Emorine L, Kuehl M, Weir L, et al. (1983). "A conserved sequence in the immunoglobulin J kappa-C kappa intron: possible enhancer element". Nature. 304 (5925): 447–9. doi:10.1038/304447a0. PMID 6308460.
• Bentley DL, Rabbitts TH (1983). "Evolution of immunoglobulin V genes: evidence indicating that recently duplicated human V kappa sequences have diverged by gene conversion". Cell. 32 (1): 181–9. doi:10.1016/0092-8674(83)90508-1. PMID 6402305.
• Hieter PA, Max EE, Seidman JG, et al. (1981). "Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments". Cell. 22 (1 Pt 1): 197–207. doi:10.1016/0092-8674(80)90168-3. PMID 6775818.
• Bentley DL, Rabbits TH (1981). "Human immunoglobulin variable region genes--DNA sequences of two V kappa genes and a pseudogene". Nature. 288 (5792): 730–3. doi:10.1038/288730a0. PMID 6779204.
• Huber C, Schäble KF, Huber E, et al. (1993). "The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line". Eur. J. Immunol. 23 (11): 2868–75. doi:10.1002/eji.1830231121. PMID 8223863.
• Olsen KE, Sletten K, Westermark P (1998). "Extended analysis of AL-amyloid protein from abdominal wall subcutaneous fat biopsy: kappa IV immunoglobulin light chain". Biochem. Biophys. Res. Commun. 245 (3): 713–6. doi:10.1006/bbrc.1998.8515. PMID 9588180.
• Wally J, Kica G, Zhang Y, et al. (1999). "Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappa1 light chain". Biochim. Biophys. Acta. 1454 (1): 49–56. doi:10.1016/s0925-4439(99)00019-8. PMID 10354514.
• Hotta K, Lange H, Tantillo DJ, et al. (2000). "Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8". J. Mol. Biol. 302 (5): 1213–25. doi:10.1006/jmbi.2000.4503. PMID 11183784.
• Karpusas M, Lucci J, Ferrant J, et al. (2001). "Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody". Structure. 9 (4): 321–9. doi:10.1016/S0969-2126(01)00590-1. PMID 11525169.
• Davis DP, Gallo G, Vogen SM, et al. (2001). "Both the environment and somatic mutations govern the aggregation pathway of pathogenic immunoglobulin light chain". J. Mol. Biol. 313 (5): 1021–34. doi:10.1006/jmbi.2001.5092. PMID 11700059.
• Pandey JP, Frederick M (2002). "TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis". Hum. Immunol. 63 (6): 485–91. doi:10.1016/S0198-8859(02)00399-3. PMID 12039524.