ILKAP

ILKAP
Identifiers
Aliases	ILKAP, ILKAP2, ILKAP3, PP2C-DELTA, PPM1O, ILK associated serine/threonine phosphatase
External IDs	MGI: 1914694 HomoloGene: 31525 GeneCards: ILKAP
Gene ontology Molecular function • protein serine/threonine phosphatase activity • protein binding • catalytic activity • phosphoprotein phosphatase activity • hydrolase activity • metal ion binding • cation binding Cellular component • cytoplasm Biological process • protein dephosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80895	67444
Ensembl	ENSG00000132323	ENSMUSG00000026309
UniProt	Q9H0C8	Q8R0F6
RefSeq (mRNA)	NM_030768 NM_176799	NM_023343
RefSeq (protein)	NP_110395.1	NP_075832.1
Location (UCSC)	Chr 2: 238.17 – 238.2 Mb	Chr 1: 91.37 – 91.4 Mb
PubMed search	[1]	[2]
Wikidata

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Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.^[3]

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.^[3]

Interactions

ILKAP has been shown to interact with Integrin-linked kinase.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2C".
4. Leung-Hagesteijn, C; Mahendra A; Naruszewicz I; Hannigan G E (May 2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". EMBO J. England. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. ISSN 0261-4189. PMC 125446. PMID 11331582.

Further reading

• Tong Y, Quirion R, Shen SH (1999). "Cloning and characterization of a novel mammalian PP2C isozyme". J. Biol. Chem. 273 (52): 35282–90. doi:10.1074/jbc.273.52.35282. PMID 9857069.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". EMBO J. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMC 125446. PMID 11331582.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kumar AS, Naruszewicz I, Wang P, et al. (2004). "ILKAP regulates ILK signaling and inhibits anchorage-independent growth". Oncogene. 23 (19): 3454–61. doi:10.1038/sj.onc.1207473. PMID 14990992.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.