L. S. Shashidhara

L. S. Shashidhara
Born	June 21, 1963 Karnataka, India
Residence	Pune. Maharashtra, India
Nationality	Indian
Fields	Genetics Developmental biology
Institutions	Centre for Cellular and Molecular Biology Indian Institutes of Science Education and Research Jawaharlal Nehru Centre for Advanced Scientific Research]]
Alma mater	University of Agricultural Sciences, Dharwad University of Cambridge National Centre for Biological Sciences
Known for	Studies on Drosophila
Notable awards	2003 CSIR Technology Prize 2006 DAE-SRC Outstanding Research Investigator Award 2008 Shanti Swarup Bhatnagar Prize

Lingadahalli Subrahmanya Shashidhara (born 1963) is an Indian developmental biologist, geneticist and a professor and chair of Biology at Indian Institutes of Science Education and Research (IISER), Pune.^[1] He heads the LSS Laboratory at IISER^[2] and is known for his studies on Drosophila, particularly Evolution of appendages and functions of homeotic selector genes.^[3] He is a J. C. Bose National Fellow of the Department of Science and Technology and an elected fellow of the Indian National Science Academy,^[4] Indian Academy of Sciences^[5] and the National Academy of Sciences, India.^[6] The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2008, for his contributions to biological sciences.^[7]

Biography

L. S. Shashidhara, born on 23 March 1963 in the south Indian state of Karnataka, graduated in science from University of Agricultural Sciences, Dharwad (UAS) in 1985 and obtained a master's degree in Genetics and Plant breeding in 1987 from the same university.^[8] After a brief stint (1987–88) at UAS as a teaching associate, he moved to University of Cambridge in 1988 for his doctoral studies to secure a PhD in 1991. On completion of his post-doctoral studies at Cambridge (1991–93), he returned to India to join National Centre for Biological Sciences and worked as a visiting fellow for two years. Subsequently, he moved to Centre for Cellular and Molecular Biology (CCMB) in 1995 as a scientist (group leader)^[9] where he served till 2007 when he was transferred, on deputation, to the Pune centre of Indian Institutes of Science Education and Research (IISER) as a professor.^[10] Since then, he has been serving the institute as a professor and chair of Biology and is the coordinator of the department of Biology.^[11] He pursues his research interests as the head of the LSS Laboratory at IISER where he hosts a number doctoral and post-doctoral scholars.^[2] He also serves as an honorary professor at Jawaharlal Nehru Centre for Advanced Scientific Research^[10] and is the incumbent vice president of the Indian National Science Academy.^[12]

Legacy

Drosophila melanogaster

Shashidhara's researches were focused on developmental biology, specifically the development of limbs and the role played by Ultrabithorax, a Hox gene, functioning as a transcription factor.^[13] Studying Drosophila melanogaster (commonly known as fruit fly) as a model, he elucidated the molecular pathways Wnt, TGF-? and EGFR/Ras that impact the growth control and developed a fly model for studying Adenomatous polyposis coli, the colon cancer gene in humans. His studies are reported to have assisted in a wider understanding of the relation between genes and diseases in humans and in the development of cancer drug discovery systems.^[4] His research findings have been published in a number of articles^{[note 1]} published in peer-reviewed journals,^[14] several of them have been listed in online article repositories such as Metascience,^[15] PubMed,^[16] and ResearchGate.^[17] He has also published many general articles on adacemics^{[note 2]} and has delivered keynote addresses and featured talks.^[18][19] He is the secretary-general of the International Union of Biological Sciences (IUBS),^[20] and is associated with the Journal of Genetics and Current Science as their associate editor and with Scientific Reports as a member of its editorial board.^[10]

Awards and honors

Shashidhara, a J. C. Bose National Fellow of the Department of Science and Technology, received the Technology Prize in Biological Sciences of the Council of Scientific and Industrial Research in 2003^[12] and the Outstanding Research Investigator Award of the Science Research Council of the Department of Atomic Energy in 2006.^[10] The Indian academy of Sciences elected him as a fellow in 2007 and he became an elected fellow of the Indian National Science Academy^[4] and the National Academy of Sciences, India in 2008. The same year he received the Shanti Swarup Bhatnagar Prize of the Council of Scientific and Industrial Research, one of the highest Indian science awards, for his contributions to Biological Sciences.^[7]

Selected bibliography

Scientific articles

• Naveen Prasad, Shreeharsha Tarikere, Dhanashree Khanale, Farhat Habib, Lingadahalli S Shashidhara (June 2016). "A comparative genomic analysis of targets of Hox protein Ultrabithorax amongst distant insect species". Scientific Reports. 1 (27885). doi:10.1038/srep27885.
• Pavan Agrawal, Lingadahalli S Shashidhara (August 2013). "ChIP for Hox Proteins from Drosophila Imaginal Discs". Methods in Molecular Biology. 1196: 241–253. doi:10.1007/978-1-4939-1242-1_15.
• Sindhu Subramaniam, Prethish Sreenivas, Sirisha Cheedipudi, Vatrapu Rami Reddy, Lingadahalli S Shashidhara, Ravi Kumar Chilukoti, Madhavi Mylavarapu, Jyotsna Dhawan (June 2013). "Distinct Transcriptional Networks in Quiescent Myoblasts: A Role for Wnt Signaling in Reversible vs. Irreversible Arrest". PLoS ONE. 8 (6). doi:10.1371/journal.pone.0065097.
• F M De Graeve, Véronique Van De Bor, C Ghiglione, Stephane Noselli (May 2012). "Drosophila apc regulates delamination of invasive epithelial clusters". Developmental Biology. 368 (1): 12. doi:10.1016/j.ydbio.2012.05.017.
• Bright Starling Emerald, Lingadahalli S Shashidhara (April 2012). "Negative regulation ofUltrabithorax expression byengrailed is required for proper specification of wing development inDrosophila melanogaster". Journal of Genetics. 1 (79): 2. doi:10.1007/BF02728947.
• Pavan Agrawal, Farhat Habib, Ramesh Yelagandula, L. S. Shashidharaa (December 2011). "Genome-level identification of targets of Hox protein Ultrabithorax in Drosophila: novel mechanisms for target selection". Scientific Reports. 1 (205). doi:10.1038/srep00205.
• N Usha, LS Shashidhara (March 2011). "The Drosophila Homologue of Ataxin-2 Binding Protein: Toward a Fruit Fly Model of Spinocerebellar Ataxia Type 2?". Alternatives to laboratory animals: ATLA. 39 (1): 70.
• P R Rao, Kalpana Makhijani, Lingadahalli S Shashidhara (May 2008). "Human APC sequesters β-catenin even in the absence of GSK-3β in a Drosophila model". Oncogene. 27 (17): 2488–93. doi:10.1038/sj.onc.1210890.

General articles

• Lingadahalli S Shashidhara (August 2004). "Edward B Lewis (1918–2004)". Journal of Genetics. 83 (2): 219. doi:10.1007/BF02729900.
• L. S. Shashidhara (July 10, 2011). "What is interdisciplinary science?". IndiaBioscience.
• L. S. Shashidhara (July 16, 2011). "Science education and research in 21st century India". IndiaBioscience.
• L. S. Shashidhara (August 3, 2011). "Postdoctoral Culture". IndiaBioscience.
• L. S. Shashidhara (August 31, 2011). "Democracy in our research organizations". IndiaBioscience.
• L. S. Shashidhara (December 3, 2011). "Understanding bureaucracy". IndiaBioscience.
• Lingadahalli S Shashidhara (September 2014). "Who are 'people of genius'?". Current science. 107 (5): 731–732.
• L. S. Shashidhara (December 16, 2015). "As IISERs enter their 10th year, a self-congratulatory note on Biology research". IndiaBioscience.

See also

• Drosophila melanogaster
• Homeotic selector gene
• Adenomatous polyposis coli
• Ultrabithorax

Notes

1. 25 of his articles are reported to be high-impact articles^[4]
2. Please see General articles section

References

1. "Brief Profile of the Awardee". Shanti Swarup Bhatnagar Prize. 2016. Retrieved October 5, 2016.
2. "LSS Lab - Home". LSS Lab - IISER. 2016. Retrieved October 26, 2016.
3. "L S Shashidhara - Biography". 2016. IISER Thiruvananthapuram. Retrieved October 26, 2016.
4. "Indian fellow - Shashidhara". Indian National Science Academy. 2016. Retrieved October 25, 2016.
5. "Fellow Profile - Shashidhara". Indian Academy of Sciences. 2016. Retrieved October 25, 2016.
6. "NASI fellows". National Academy of Sciences, India. 2016. Retrieved October 26, 2016.
7. "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved October 5, 2016.
8. "Brief Biodata". Centre for Cellular and Molecular Biology. 2016. Retrieved October 26, 2016.
9. "Drosophila Genetics & Developmental Biology". CCMB. 2016. Retrieved October 26, 2016.
10. "Prof. LS Shashidhara - LSS Lab". IISER, PUne. 2016. Retrieved October 26, 2016.
11. "Coordinator - Department of Biology". Open Access Biomedical Image Search Engine. 2016. Retrieved October 26, 2016.
12. "Prof. LS Shashidhara elected Vice President of the Indian National Science Academy". IISER Pune News. January 13, 2016. Retrieved October 26, 2016.
13. "Handbook of Shanti Swarup Bhatnagar Prize Winners" (PDF). Council of Scientific and Industrial Research. 1999. p. 34. Retrieved October 5, 2016.
14. "Publication by Fellows". Article listing. Indian Academy of Sciences. 2016. Retrieved October 26, 2016.
15. "Lingadahalli Subrahmanya Shashidhara on Metascience". Metascience. 2016. Retrieved October 26, 2016.
16. Author profile (2016). "Shashidhara on PubMed". PubMed. Retrieved October 26, 2016.
17. "Lingadahalli S Shashidhara on ResearchGate". ResearchGate. 2016. Retrieved October 26, 2016.
18. L. S. Shashidhara (March 11, 2010). "Behavioural Adaptations and Evolution". Featured talk. Centre for the Study of Culture and Society. Retrieved October 26, 2016.
19. "Cell Biology of Organ Development in Drosophila". IISER. December 7, 2015. Retrieved October 26, 2016.
20. "IUBS Officers and Executive Committee Members". International Union of Biological Sciences. 2016. Retrieved October 26, 2016.

External links

• L. S. Shashidhara (2010). "Hox genes and evolution of body plan" (PDF). Lecture - full text. Indian Institute of Science Education and Research. Retrieved October 26, 2016.
• L. S. Shashidhara (September 22, 2010). "NCBS talk 1". Lecture - YouTube video. TheNCBSnewsteam's channel. Retrieved October 26, 2016.