LHX2

LHX2
Identifiers
Aliases	LHX2, LH2, hLhx2, LIM homeobox 2
External IDs	MGI: 96785 HomoloGene: 55848 GeneCards: LHX2
Gene ontology Molecular function • metal ion binding • sequence-specific DNA binding • chromatin binding • zinc ion binding • transcription factor activity, RNA polymerase II transcription factor binding • DNA binding Cellular component • nucleus • intracellular Biological process • negative regulation of transcription regulatory region DNA binding • mesoderm development • telencephalon development • neural tube closure • retina development in camera-type eye • cerebral cortex development • transcription, DNA-templated • axon guidance • axon extension • hair follicle development • maintenance of epithelial cell apical/basal polarity • neurogenesis • brain development • olfactory bulb development • nervous system development • dorsal/ventral pattern formation • positive regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • neuron differentiation • anatomical structure formation involved in morphogenesis • telencephalon regionalization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9355	16870
Ensembl	ENSG00000106689	ENSMUSG00000000247
UniProt	P50458	Q9Z0S2
RefSeq (mRNA)	NM_004789	NM_001290646 NM_010710
RefSeq (protein)	NP_004780.3	NP_034840.1
Location (UCSC)	Chr 9: 124 – 124.03 Mb	Chr 2: 38.34 – 38.37 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.^[3][4][5]

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.^[5]

Interactions

LHX2 has been shown to interact with CITED2.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (Jul 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene. 12 (6): 1205–12. PMID 8649822.
4. Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (Apr 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A. 96 (5): 2165–70. doi:10.1073/pnas.96.5.2165. PMC 26754. PMID 10051612.
5. "Entrez Gene: LHX2 LIM homeobox 2".
6. Glenn, D J; Maurer R A (Dec 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. UNITED STATES. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. ISSN 0021-9258. PMID 10593900.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Glenn DJ, Maurer RA (2000). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. PMID 10593900.
• Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247.
• Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C (1998). "Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity". Differentiation. 63 (3): 151–7. doi:10.1046/j.1432-0436.1998.6330151.x. PMID 9697309.