LIN7B

LIN7B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DKR
Identifiers
Aliases	LIN7B, LIN-7B, MALS-2, MALS2, VELI2, lin-7 homolog B, crumbs cell polarity complex component
External IDs	MGI: 1330858 HomoloGene: 22648 GeneCards: LIN7B
Gene ontology Molecular function • PDZ domain binding • protein domain specific binding Cellular component • postsynaptic membrane • postsynaptic density • membrane • cell-cell junction • bicellular tight junction • plasma membrane • cell junction • basolateral plasma membrane • neuron projection • synapse • presynapse Biological process • protein localization to basolateral plasma membrane • maintenance of epithelial cell apical/basal polarity • transport • protein transport • neurotransmitter secretion • exocytosis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64130	22342
Ensembl	ENSG00000104863	ENSMUSG00000003872
UniProt	Q9HAP6	O88951
RefSeq (mRNA)	NM_001308419 NM_022165	NM_011698
RefSeq (protein)	NP_001295348.1 NP_071448.1	NP_035828.1
Location (UCSC)	Chr 19: 49.11 – 49.12 Mb	Chr 7: 45.37 – 45.37 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Lin-7 homolog B is a protein that in humans is encoded by the LIN7B gene.^[3][4]

Interactions

LIN7B has been shown to interact with:

• ACCN3,^[5]
• GRIN2B,^[3]
• KCNJ12^[6][7] and
• KCNJ4.^[8]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. PMID 10341223.
4. "Entrez Gene: LIN7B lin-7 homolog B (C. elegans)".
5. Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (Nov 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
6. Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
7. Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
8. Olsen O, Liu H, Wade JB, Merot J, Welling PA (Jan 2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. 282 (1): C183–95. doi:10.1152/ajpcell.00249.2001. PMID 11742811.

Further reading

• Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.". Cell. 94 (6): 773–82. doi:10.1016/S0092-8674(00)81736-5. PMID 9753324.
• Olsen O, Liu H, Wade JB, Merot J, Welling PA (2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex.". Am. J. Physiol., Cell Physiol. 282 (1): C183–95. doi:10.1152/ajpcell.00249.2001. PMID 11742811.
• Coussen F, Normand E, Marchal C, Costet P, Choquet D, Lambert M, Mège RM, Mulle C (2002). "Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes.". J. Neurosci. 22 (15): 6426–36. PMID 12151522.
• Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts.". FEBS Lett. 554 (1-2): 30–4. doi:10.1016/S0014-5793(03)01074-3. PMID 14596909.
• Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
• Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
• Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current.". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
• Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW (2006). "Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux.". J. Biol. Chem. 280 (47): 39653–64. doi:10.1074/jbc.M510187200. PMID 16192269.
• Kawai S, Fukuda C, Mukai T, Murata K (2006). "MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase.". J. Biol. Chem. 280 (47): 39200–7. doi:10.1074/jbc.M506426200. PMID 16192277.
• Li Z, Benard O, Margolskee RF (2006). "Ggamma13 interacts with PDZ domain-containing proteins.". J. Biol. Chem. 281 (16): 11066–73. doi:10.1074/jbc.M600113200. PMID 16473877.
• Sudo K, Ito H, Iwamoto I, Morishita R, Asano T, Nagata K (2007). "Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons.". Neurosci. Res. 56 (4): 347–55. doi:10.1016/j.neures.2006.08.003. PMID 16979770.