LOC4951

OCM2
Identifiers
Aliases	OCM2, OCM, LOC4951, oncomodulin 2
External IDs	HomoloGene: 130549 GeneCards: OCM2
Orthologs
Species	Human	Mouse
Entrez	4951	n/a
Ensembl	ENSG00000135175	n/a
UniProt	P0CE71	n/a
RefSeq (mRNA)	NM_006188	n/a
RefSeq (protein)	NP_006179.2	n/a
Location (UCSC)	Chr 7: 97.98 – 97.99 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Oncomodulin, also known as OCM, is a human gene.^[2]

Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. Oncomodulin is an oncodevelopmental protein found in early embryonic cells in the placenta and also in tumors.^[2]

References

1. "Human PubMed Reference:".
2. "Entrez Gene: OCM oncomodulin".

Further reading

• Pauls TL, Cox JA, Berchtold MW (1996). "The Ca2+(-)binding proteins parvalbumin and oncomodulin and their genes: new structural and functional findings.". Biochim. Biophys. Acta. 1306 (1): 39–54. doi:10.1016/0167-4781(95)00221-9. PMID 8611623.
• Belkacemi L, Simoneau L, Lafond J (2003). "Calcium-binding proteins: distribution and implication in mammalian placenta.". Endocrine. 19 (1): 57–64. doi:10.1385/ENDO:19:1:57. PMID 12583602.
• Ritzler JM, Sawhney R, Geurts van Kessel AH, et al. (1992). "The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome.". Genomics. 12 (3): 567–72. doi:10.1016/0888-7543(92)90449-3. PMID 1559707.
• Palmer EJ, MacManus JP, Mutus B (1990). "Inhibition of glutathione reductase by oncomodulin.". Arch. Biochem. Biophys. 277 (1): 149–54. doi:10.1016/0003-9861(90)90563-E. PMID 2306116.
• Mutus B, Palmer EJ, MacManus JP (1988). "Disulfide-linked dimer of oncomodulin: comparison to calmodulin.". Biochemistry. 27 (15): 5615–22. doi:10.1021/bi00415a033. PMID 3179268.
• Gillen MF, Banville D, Rutledge RG, et al. (1987). "A complete complementary DNA for the oncodevelopmental calcium-binding protein, oncomodulin.". J. Biol. Chem. 262 (11): 5308–12. PMID 3558395.
• MacManus JP, Brewer LM, Whitfield JF (1985). "The widely-distributed tumour protein, oncomodulin, is a normal constituent of human and rodent placentas.". Cancer Lett. 27 (2): 145–51. doi:10.1016/0304-3835(85)90103-X. PMID 4005827.
• Blum JK, Berchtold MW (1994). "Calmodulin-like effect of oncomodulin on cell proliferation.". J. Cell. Physiol. 160 (3): 455–62. doi:10.1002/jcp.1041600308. PMID 8077283.
• Föhr UG, Weber BR, Müntener M, et al. (1993). "Human alpha and beta parvalbumins. Structure and tissue-specific expression.". Eur. J. Biochem. 215 (3): 719–27. doi:10.1111/j.1432-1033.1993.tb18084.x. PMID 8354278.
• Sakaguchi N, Henzl MT, Thalmann I, et al. (2000). "Oncomodulin is expressed exclusively by outer hair cells in the organ of Corti.". J. Histochem. Cytochem. 46 (1): 29–40. doi:10.1177/002215549804600105. PMID 9405492.
• "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Babini E, Bertini I, Capozzi F, et al. (2005). "Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs". Biochemistry. 43 (51): 16076–85. doi:10.1021/bi048388o. PMID 15610002.