List of EC numbers (EC 6)

This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.

EC 6.1: Forming Carbon-Oxygen Bonds

EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds (Aminoacyl tRNA synthetase)

EC 6.1.2: Acid—alcohol ligases (ester synthases)

EC 6.1.2.1: D-alanine—(R)-lactate ligase

EC 6.2: Forming Carbon-Sulfur Bonds

EC 6.2.1: Acid-Thiol Ligases

EC 6.3: Forming Carbon-Nitrogen Bonds

EC 6.3.1: Acid-Ammonia (or Amine) Ligases (Amide Synthases)

EC 6.3.2: Acid-Amino-Acid Ligases (Peptide Synthases)

EC 6.3.2.1: pantoate-b-alanine ligase
EC 6.3.2.2: glutamate-cysteine ligase
EC 6.3.2.3: glutathione synthase
EC 6.3.2.4: D-alanine-D-alanine ligase
EC 6.3.2.5: phosphopantothenate-cysteine ligase
EC 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase
EC 6.3.2.7: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase
EC 6.3.2.8: UDP-N-acetylmuramate-L-alanine ligase
EC 6.3.2.9: UDP-N-acetylmuramoylalanine-D-glutamate ligase
EC 6.3.2.10: UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase
EC 6.3.2.11: carnosine synthase
EC 6.3.2.12: dihydrofolate synthase
EC 6.3.2.13: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diamino-pimelate ligase
EC 6.3.2.14: 2,3-dihydroxybenzoate-serine ligase
EC 6.3.2.15: Deleted, due to EC 6.3.2.10
EC 6.3.2.16: D-alanine-alanyl-poly(glycerolphosphate) ligase
EC 6.3.2.17: tetrahydrofolate synthase
EC 6.3.2.18: g-glutamylhistamine synthase
EC 6.3.2.19: ubiquitin-protein ligase
EC 6.3.2.20: indoleacetate-lysine synthetase
EC 6.3.2.21: ubiquitin-calmodulin ligase
EC 6.3.2.22: Now EC 6.3.1.14
EC 6.3.2.23: homoglutathione synthase
EC 6.3.2.24: tyrosine-arginine ligase
EC 6.3.2.25: tubulin-tyrosine ligase
EC 6.3.2.26: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
EC 6.3.2.27: The activity is covered by two independent enzymes, EC 6.3.2.38 N²-citryl-N⁶-acetyl-N⁶-hydroxylysine synthase, and EC 6.3.2.39, aerobactin synthase
EC 6.3.2.28: L-amino-acid alpha-ligase
EC 6.3.2.29: cyanophycin synthase (L-aspartate-adding)
EC 6.3.2.30: cyanophycin synthase (L-arginine-adding)
EC 6.3.2.31: coenzyme F420-0:L-glutamate ligase
EC 6.3.2.32: coenzyme gamma-F420-2:alpha-L-glutamate ligase
EC 6.3.2.33: tetrahydrosarcinapterin synthase
EC 6.3.2.34: coenzyme F420-1:gamma-L-glutamate ligase
EC 6.3.2.35: D-alanine---D-serine ligase
EC 6.3.2.36: 4-phosphopantoate---beta-alanine ligase
EC 6.3.2.37: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---D-lysine ligase
EC 6.3.2.38: N2-citryl-N6-acetyl-N6-hydroxylysine synthase
EC 6.3.2.39: aerobactin synthase

EC 6.3.3: Cyclo-Ligases

EC 6.3.4: Other Carbon-Nitrogen Ligases

EC 6.3.4.1: GMP synthase. Now included in EC 6.3.5.2, GMP synthase (glutamine—hydrolysing).
EC 6.3.4.2: CTP synthase
EC 6.3.4.3: formate-tetrahydrofolate ligase
EC 6.3.4.4: adenylosuccinate synthase
EC 6.3.4.5: argininosuccinate synthase
EC 6.3.4.6: urea carboxylase
EC 6.3.4.7: ribose-5-phosphate-ammonia ligase
EC 6.3.4.8: imidazoleacetate-phosphoribosyldiphosphate ligase
EC 6.3.4.9: biotin-(methylmalonyl-CoA-carboxytransferase) ligase
EC 6.3.4.10: biotin-(propionyl-CoA-carboxylase (ATP-hydrolysing)) ligase
EC 6.3.4.11: biotin-(methylcrotonoyl-CoA-carboxylase) ligase
EC 6.3.4.12: glutamate-methylamine ligase
EC 6.3.4.13: phosphoribosylamine-glycine ligase
EC 6.3.4.14: biotin carboxylase
EC 6.3.4.15: biotin-(acetyl-CoA-carboxylase) ligase
EC 6.3.4.16: carbamoyl-phosphate synthase (ammonia)
EC 6.3.4.17: formate-dihydrofolate ligase
EC 6.3.4.18: 5-(carboxyamino)imidazole ribonucleotide synthase
EC 6.3.4.19: tRNAIle-lysidine synthase
EC 6.3.4.20: 7-cyano-7-deazaguanine synthase
EC 6.3.4.21: nicotinate phosphoribosyltransferase

EC 6.3.5: Carbon-Nitrogen Ligases with Glutamine as Amido-N-Donor

EC 6.4: Forming Carbon-Carbon Bonds

EC 6.5: Forming Phosphoric Ester Bonds

EC 6.6: Forming Nitrogen-Metal Bonds

EC 6.6.1: Forming Coordination Complexes

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

Enzymes: CO CS and CN ligases (EC 6.1-6.3)

6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine

6.2: Carbon-Sulfur	Succinyl coenzyme A synthetase Acetyl—CoA synthetase Long-chain-fatty-acid—CoA ligase

6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

Ligases: carbon-carbon ligases (EC 6.4)

Biotin dependent carboxylation	Pyruvate carboxylase Acetyl-CoA carboxylase Propionyl-CoA carboxylase Methylcrotonyl-CoA carboxylase

Other	Polyketide synthase

Enzymes: Phosphoric ester and nitrogen-metal ligases (EC 6.5-6.6)

6.5: Phosphoric Ester	DNA ligase

6.6: Nitrogen-Metal	Magnesium chelatase Cobalt chelatase

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