List of EC numbers (EC 4)

This list contains a list of EC numbers for the fourth group, EC 4, lyases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.

EC 4.1: Carbon-Carbon Lyases

EC 4.1.1: Carboxy-Lyases

• EC 4.1.1.1: pyruvate decarboxylase
• EC 4.1.1.2: oxalate decarboxylase
• EC 4.1.1.3: oxaloacetate decarboxylase
• EC 4.1.1.4: acetoacetate decarboxylase
• EC 4.1.1.5: acetolactate decarboxylase
• EC 4.1.1.6: aconitate decarboxylase
• EC 4.1.1.7: benzoylformate decarboxylase
• EC 4.1.1.8: oxalyl-CoA decarboxylase
• EC 4.1.1.9: malonyl-CoA decarboxylase
• EC 4.1.1.10: deleted, included in EC 4.1.1.12
• EC 4.1.1.11: aspartate 1-decarboxylase
• EC 4.1.1.12: aspartate 4-decarboxylase
• EC 4.1.1.13: deleted
• EC 4.1.1.14: valine decarboxylase
• EC 4.1.1.15: glutamate decarboxylase
• EC 4.1.1.16: hydroxyglutamate decarboxylase
• EC 4.1.1.17: ornithine decarboxylase
• EC 4.1.1.18: lysine decarboxylase
• EC 4.1.1.19: arginine decarboxylase
• EC 4.1.1.20: diaminopimelate decarboxylase
• EC 4.1.1.21: phosphoribosylaminoimidazole carboxylase
• EC 4.1.1.22: histidine decarboxylase
• EC 4.1.1.23: orotidine-5'-phosphate decarboxylase
• EC 4.1.1.24: aminobenzoate decarboxylase
• EC 4.1.1.25: tyrosine decarboxylase
• EC 4.1.1.26: deleted, included in EC 4.1.1.28
• EC 4.1.1.27: deleted, included in EC 4.1.1.28
• EC 4.1.1.28: aromatic-L-amino-acid decarboxylase
• EC 4.1.1.29: sulfoalanine decarboxylase
• EC 4.1.1.30: pantothenoylcysteine decarboxylase
• EC 4.1.1.31: phosphoenolpyruvate carboxylase
• EC 4.1.1.32: phosphoenolpyruvate carboxykinase (GTP)
• EC 4.1.1.33: diphosphomevalonate decarboxylase
• EC 4.1.1.34: dehydro-L-gulonate decarboxylase
• EC 4.1.1.35: UDP-glucuronate decarboxylase
• EC 4.1.1.36: phosphopantothenoylcysteine decarboxylase
• EC 4.1.1.37: uroporphyrinogen decarboxylase
• EC 4.1.1.38: phosphoenolpyruvate carboxykinase (diphosphate)
• EC 4.1.1.39: ribulose-bisphosphate carboxylase
• EC 4.1.1.40: hydroxypyruvate decarboxylase
• EC 4.1.1.41: methylmalonyl-CoA decarboxylase
• EC 4.1.1.42: carnitine decarboxylase
• EC 4.1.1.43: phenylpyruvate decarboxylase
• EC 4.1.1.44: 4-carboxymuconolactone decarboxylase
• EC 4.1.1.45: aminocarboxymuconate-semialdehyde decarboxylase
• EC 4.1.1.46: o-pyrocatechuate decarboxylase
• EC 4.1.1.47: tartronate-semialdehyde synthase
• EC 4.1.1.48: indole-3-glycerol-phosphate synthase
• EC 4.1.1.49: phosphoenolpyruvate carboxykinase (ATP)
• EC 4.1.1.50: adenosylmethionine decarboxylase
• EC 4.1.1.51: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase
• EC 4.1.1.52: 6-methylsalicylate decarboxylase
• EC 4.1.1.53: phenylalanine decarboxylase
• EC 4.1.1.54: dihydroxyfumarate decarboxylase
• EC 4.1.1.55: 4,5-dihydroxyphthalate decarboxylase
• EC 4.1.1.56: 3-oxolaurate decarboxylase
• EC 4.1.1.57: methionine decarboxylase
• EC 4.1.1.58: orsellinate decarboxylase
• EC 4.1.1.59: gallate decarboxylase
• EC 4.1.1.60: stipitatonate decarboxylase
• EC 4.1.1.61: 4-hydroxybenzoate decarboxylase
• EC 4.1.1.62: gentisate decarboxylase
• EC 4.1.1.63: protocatechuate decarboxylase
• EC 4.1.1.64: 2,2-dialkylglycine decarboxylase (pyruvate)
• EC 4.1.1.65: phosphatidylserine decarboxylase
• EC 4.1.1.66: uracil-5-carboxylate decarboxylase
• EC 4.1.1.67: UDP-galacturonate decarboxylase
• EC 4.1.1.68: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase
• EC 4.1.1.69: 3,4-dihydroxyphthalate decarboxylase
• EC 4.1.1.70: glutaconyl-CoA decarboxylase
• EC 4.1.1.71: 2-oxoglutarate decarboxylase
• EC 4.1.1.72: branched-chain-2-oxoacid decarboxylase
• EC 4.1.1.73: tartrate decarboxylase
• EC 4.1.1.74: indolepyruvate decarboxylase
• EC 4.1.1.75: 5-guanidino-2-oxopentanoate decarboxylase
• EC 4.1.1.76: arylmalonate decarboxylase
• EC 4.1.1.77: 4-oxalocrotonate decarboxylase
• EC 4.1.1.78: acetylenedicarboxylate decarboxylase
• EC 4.1.1.79: sulfopyruvate decarboxylase
• EC 4.1.1.80: 4-hydroxyphenylpyruvate decarboxylase
• EC 4.1.1.81: threonine-phosphate decarboxylase
• EC 4.1.1.82: phosphonopyruvate decarboxylase
• EC 4.1.1.83: 4-hydroxyphenylacetate decarboxylase
• EC 4.1.1.84: D-dopachrome decarboxylase
• EC 4.1.1.85: 3-dehydro-L-gulonate-6-phosphate decarboxylase
• EC 4.1.1.86: diaminobutyrate decarboxylase
• EC 4.1.1.87: malonyl-S-ACP decarboxylase
• EC 4.1.1.88: biotin-independent malonate decarboxylase
• EC 4.1.1.89: biotin-dependent malonate decarboxylase
• EC 4.1.1.90: peptidyl-glutamate 4-carboxylase
• EC 4.1.1.91: salicylate decarboxylase
• EC 4.1.1.92: indole-3-carboxylate decarboxylase
• EC 4.1.1.93: pyrrole-2-carboxylate decarboxylase
• EC 4.1.1.94: ethylmalonyl-CoA decarboxylase
• EC 4.1.1.95: L-glutamyl-(BtrI acyl-carrier protein) decarboxylase
• EC 4.1.1.96: carboxynorspermidine decarboxylase

EC 4.1.2: Aldehyde-Lyases

• EC 4.1.2.1: deleted, included in EC 4.1.3.16
• EC 4.1.2.2: ketotetrose-phosphate aldolase
• EC 4.1.2.3: deleted, was pentosealdolase.
• EC 4.1.2.4: deoxyribose-phosphate aldolase
• EC 4.1.2.5: threonine aldolase
• EC 4.1.2.6: deleted entry, was allothreonine aldolase. Reaction is due to EC 2.1.2.1 glycine hydroxymethyltransferase. See also EC 4.1.2.49.
• EC 4.1.2.7: deleted, included in EC 4.1.2.13
• EC 4.1.2.8: indole-3-glycerol-phosphate lyase^[1][2]
• EC 4.1.2.9: phosphoketolase
• EC 4.1.2.10: mandelonitrile lyase
• EC 4.1.2.11: hydroxymandelonitrile lyase
• EC 4.1.2.12: 2-dehydropantoate aldolase
• EC 4.1.2.13: fructose-bisphosphate aldolase
• EC 4.1.2.14: 2-dehydro-3-deoxy-phosphogluconate aldolase
• EC 4.1.2.15: now EC 2.5.1.54
• EC 4.1.2.16: now EC 2.5.1.55
• EC 4.1.2.17: L-fuculose-phosphate aldolase
• EC 4.1.2.18: 2-dehydro-3-deoxy-L-pentonate aldolase
• EC 4.1.2.19: rhamnulose-1-phosphate aldolase
• EC 4.1.2.20: 2-dehydro-3-deoxyglucarate aldolase
• EC 4.1.2.21: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
• EC 4.1.2.22: fructose-6-phosphate phosphoketolase
• EC 4.1.2.23: 3-deoxy-D-manno-octulosonate aldolase
• EC 4.1.2.24: dimethylaniline-N-oxide aldolase
• EC 4.1.2.25: dihydroneopterin aldolase
• EC 4.1.2.26: phenylserine aldolase
• EC 4.1.2.27: sphinganine-1-phosphate aldolase
• EC 4.1.2.28: 2-dehydro-3-deoxy-D-pentonate aldolase
• EC 4.1.2.29: 5-dehydro-2-deoxyphosphogluconate aldolase
• EC 4.1.2.30: 17a-hydroxyprogesterone aldolase
• EC 4.1.2.31: deleted, included in EC 4.1.3.16
• EC 4.1.2.32: trimethylamine-oxide aldolase
• EC 4.1.2.33: fucosterol-epoxide lyase
• EC 4.1.2.34: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase
• EC 4.1.2.35: propioin synthase
• EC 4.1.2.36: lactate aldolase
• EC 4.1.2.37: hydroxynitrilase
• EC 4.1.2.38: benzoin aldolase
• EC 4.1.2.39: Deleted, same as EC 4.1.2.37
• EC 4.1.2.40: tagatose-bisphosphate aldolase
• EC 4.1.2.41: vanillin synthase
• EC 4.1.2.42: D-threonine aldolase
• EC 4.1.2.43: 3-hexulose-6-phosphate synthase
• EC 4.1.2.44: benzoyl-CoA-dihydrodiol lyase
• EC 4.1.2.45: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
• EC 4.1.2.46: aliphatic (R)-hydroxynitrile lyase
• EC 4.1.2.47: (S)-hydroxynitrile lyase
• EC 4.1.2.48: low-specificity L-threonine aldolase
• EC 4.1.2.49: L-allo-threonine aldolase
• EC 4.1.2.50: 6-carboxytetrahydropterin synthase

EC 4.1.3: Oxo-Acid-Lyases

• EC 4.1.3.1: isocitrate lyase
• EC 4.1.3.2: now EC 2.3.3.9
• EC 4.1.3.3: N-acetylneuraminate lyase
• EC 4.1.3.4: hydroxymethylglutaryl-CoA lyase
• EC 4.1.3.5: now EC 2.3.3.10
• EC 4.1.3.6: citrate (pro-3S)-lyase
• EC 4.1.3.7: now EC 2.3.3.1
• EC 4.1.3.8: now EC 2.3.3.8
• EC 4.1.3.9: now EC 2.3.3.11
• EC 4.1.3.10: now EC 2.3.3.7
• EC 4.1.3.11: now EC 2.3.3.12
• EC 4.1.3.12: now EC 2.3.3.13
• EC 4.1.3.13: oxalomalate lyase
• EC 4.1.3.14: 3-hydroxyaspartate aldolase
• EC 4.1.3.15: now EC 2.2.1.5
• EC 4.1.3.16: 4-hydroxy-2-oxoglutarate aldolase
• EC 4.1.3.17: 4-hydroxy-4-methyl-2-oxoglutarate aldolase
• EC 4.1.3.18: now EC 2.2.1.6
• EC 4.1.3.19: now EC 2.5.1.56
• EC 4.1.3.20: now EC 2.5.1.57
• EC 4.1.3.21: now EC 2.3.3.14
• EC 4.1.3.22: citramalate lyase
• EC 4.1.3.23: now EC 2.3.3.2
• EC 4.1.3.24: malyl-CoA lyase
• EC 4.1.3.25: citramalyl-CoA lyase
• EC 4.1.3.26: 3-hydroxy-3-isohexenylglutaryl-CoA lyase
• EC 4.1.3.27: anthranilate synthase
• EC 4.1.3.28: now EC 2.3.3.3
• EC 4.1.3.29: now EC 2.3.3.4
• EC 4.1.3.30: methylisocitrate lyase
• EC 4.1.3.31: now EC 2.3.3.5
• EC 4.1.3.32: 2,3-dimethylmalate lyase
• EC 4.1.3.33: now EC 2.3.3.6
• EC 4.1.3.34: citryl-CoA lyase
• EC 4.1.3.35: (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase
• EC 4.1.3.36: naphthoate synthase
• EC 4.1.3.37: now EC 2.2.1.7
• EC 4.1.3.38: aminodeoxychorismate lyase
• EC 4.1.3.39: 4-hydroxy-2-oxovalerate aldolase
• EC 4.1.3.40: chorismate lyase
• EC 4.1.3.41: 3-hydroxy-D-aspartate aldolase

EC 4.1.99: Other Carbon-Carbon Lyases

• EC 4.1.99.1: tryptophanase
• EC 4.1.99.2: tyrosine phenol-lyase
• EC 4.1.99.3: deoxyribodipyrimidine photo-lyase
• EC 4.1.99.4: now EC 3.5.99.7
• EC 4.1.99.5: octadecanal decarbonylase
• EC 4.1.99.6: now EC 4.2.3.6
• EC 4.1.99.7: now EC 4.2.3.9
• EC 4.1.99.8: now EC 4.2.3.14
• EC 4.1.99.9: now EC 4.2.3.15
• EC 4.1.99.10: now EC 4.2.3.16
• EC 4.1.99.11: benzylsuccinate synthase
• EC 4.1.99.12: 3,4-dihydroxy-2-butanone-4-phosphate synthase
• EC 4.1.99.13: (6-4)DNA photolyase
• EC 4.1.99.14: spore photoproduct lyase
• EC 4.1.99.15: S-specific spore photoproduct lyase
• EC 4.1.99.16: geosmin synthase
• EC 4.1.99.17: phosphomethylpyrimidine synthase
• EC 4.1.99.18: cyclic pyranopterin monophosphate synthase
• EC 4.1.99.19: 2-iminoacetate synthase

EC 4.2: Carbon-Oxygen Lyases

EC 4.2.1: Hydro-lyases

• EC 4.2.1.1: carbonate dehydratase
• EC 4.2.1.2: fumarate hydratase
• EC 4.2.1.3: aconitate hydratase
• EC 4.2.1.4: citrate dehydratase
• EC 4.2.1.5: arabinonate dehydratase
• EC 4.2.1.6: galactonate dehydratase
• EC 4.2.1.7: altronate dehydratase
• EC 4.2.1.8: mannonate dehydratase
• EC 4.2.1.9: dihydroxy-acid dehydratase
• EC 4.2.1.10: 3-dehydroquinate dehydratase
• EC 4.2.1.11: phosphopyruvate hydratase
• EC 4.2.1.12: phosphogluconate dehydratase
• EC 4.2.1.13: now EC 4.3.1.17
• EC 4.2.1.14: now EC 4.3.1.18
• EC 4.2.1.15: now EC 4.4.1.1
• EC 4.2.1.16: now EC 4.3.1.19
• EC 4.2.1.17: enoyl-CoA hydratase
• EC 4.2.1.18: methylglutaconyl-CoA hydratase
• EC 4.2.1.19: imidazoleglycerol-phosphate dehydratase
• EC 4.2.1.20: tryptophan synthase
• EC 4.2.1.21: now EC 4.2.1.22
• EC 4.2.1.22: cystathionine b-synthase
• EC 4.2.1.23: deleted (methylcysteine synthase)
• EC 4.2.1.24: porphobilinogen synthase
• EC 4.2.1.25: L-arabinonate dehydratase
• EC 4.2.1.26: now EC 4.3.1.21
• EC 4.2.1.27: acetylenecarboxylate hydratase
• EC 4.2.1.28: propanediol dehydratase
• EC 4.2.1.29: now EC 4.99.1.6
• EC 4.2.1.30: glycerol dehydratase
• EC 4.2.1.31: maleate hydratase
• EC 4.2.1.32: L(+)-tartrate dehydratase
• EC 4.2.1.33: 3-isopropylmalate dehydratase
• EC 4.2.1.34: (S)-2-methylmalate dehydratase
• EC 4.2.1.35: (R)-2-methylmalate dehydratase
• EC 4.2.1.36: homoaconitate hydratase
• EC 4.2.1.37: now EC 3.3.2.4
• EC 4.2.1.38: now EC 4.3.1.20
• EC 4.2.1.39: gluconate dehydratase
• EC 4.2.1.40: glucarate dehydratase
• EC 4.2.1.41: 5-dehydro-4-deoxyglucarate dehydratase
• EC 4.2.1.42: galactarate dehydratase
• EC 4.2.1.43: 2-dehydro-3-deoxy-L-arabinonate dehydratase
• EC 4.2.1.44: myo-inosose-2 dehydratase
• EC 4.2.1.45: CDP-glucose 4,6-dehydratase
• EC 4.2.1.46: dTDP-glucose 4,6-dehydratase
• EC 4.2.1.47: GDP-mannose 4,6-dehydratase
• EC 4.2.1.48: D-glutamate cyclase
• EC 4.2.1.49: urocanate hydratase
• EC 4.2.1.50: pyrazolylalanine synthase
• EC 4.2.1.51: prephenate dehydratase
• EC 4.2.1.52: dihydrodipicolinate synthase
• EC 4.2.1.53: oleate hydratase
• EC 4.2.1.54: lactoyl-CoA dehydratase
• EC 4.2.1.55: 3-hydroxybutyryl-CoA dehydratase
• EC 4.2.1.56: itaconyl-CoA hydratase
• EC 4.2.1.57: isohexenylglutaconyl-CoA hydratase
• EC 4.2.1.58: crotonoyl-(acyl-carrier-protein) hydratase
• EC 4.2.1.59: 3-hydroxyoctanoyl-(acyl-carrier-protein) dehydratase
• EC 4.2.1.60: 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase
• EC 4.2.1.61: 3-hydroxypalmitoyl-(acyl-carrier-protein) dehydratase
• EC 4.2.1.62: 5a-hydroxysteroid dehydratase
• EC 4.2.1.63: now EC 3.3.2.3
• EC 4.2.1.64: now EC 3.3.2.3
• EC 4.2.1.65: 3-cyanoalanine hydratase
• EC 4.2.1.66: cyanide hydratase
• EC 4.2.1.67: D-fuconate dehydratase
• EC 4.2.1.68: L-fuconate dehydratase
• EC 4.2.1.69: cyanamide hydratase
• EC 4.2.1.70: pseudouridylate synthase
• EC 4.2.1.71: identical to EC 4.2.1.27
• EC 4.2.1.72: now EC 4.1.1.78
• EC 4.2.1.73: protoaphin-aglucone dehydratase (cyclizing)
• EC 4.2.1.74: long-chain-enoyl-CoA hydratase
• EC 4.2.1.75: uroporphyrinogen-III synthase
• EC 4.2.1.76: UDP-glucose 4,6-dehydratase
• EC 4.2.1.77: trans-L-3-hydroxyproline dehydratase
• EC 4.2.1.78: (S)-norcoclaurine synthase
• EC 4.2.1.79: 2-methylcitrate dehydratase
• EC 4.2.1.80: 2-oxopent-4-enoate hydratase
• EC 4.2.1.81: D(-)-tartrate dehydratase
• EC 4.2.1.82: xylonate dehydratase
• EC 4.2.1.83: 4-oxalmesaconate hydratase
• EC 4.2.1.84: nitrile hydratase
• EC 4.2.1.85: dimethylmaleate hydratase
• EC 4.2.1.86: deleted identical to EC 4.2.1.98
• EC 4.2.1.87: octopamine dehydratase
• EC 4.2.1.88: synephrine dehydratase
• EC 4.2.1.89: carnitine dehydratase
• EC 4.2.1.90: L-rhamnonate dehydratase
• EC 4.2.1.91: arogenate dehydratase
• EC 4.2.1.92: hydroperoxide dehydratase
• EC 4.2.1.93: ATP-dependent NAD(P)H-hydrate dehydratase
• EC 4.2.1.94: scytalone dehydratase
• EC 4.2.1.95: kievitone hydratase
• EC 4.2.1.96: 4a-hydroxytetrahydrobiopterin dehydratase
• EC 4.2.1.97: phaseollidin hydratase
• EC 4.2.1.98: 16a-hydroxyprogesterone dehydratase
• EC 4.2.1.99: 2-methylisocitrate dehydratase
• EC 4.2.1.100: cyclohexa-1,5-dienecarbonyl-CoA hydratase
• EC 4.2.1.101: trans-feruloyl-CoA hydratase
• EC 4.2.1.102: now EC 4.2.1.100
• EC 4.2.1.103: cyclohexyl-isocyanide hydratase
• EC 4.2.1.104: cyanate hydratase
• EC 4.2.1.105: 2-hydroxyisoflavanone dehydratase
• EC 4.2.1.106: bile-acid 7a-dehydratase
• EC 4.2.1.107: 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA dehydratase
• EC 4.2.1.108: ectoine synthase
• EC 4.2.1.109: methylthioribulose 1-phosphate dehydratase
• EC 4.2.1.110: aldos-2-ulose dehydratase
• EC 4.2.1.111: 1,5-anhydro-D-fructose dehydratase
• EC 4.2.1.112: acetylene hydratase
• EC 4.2.1.113: o-succinylbenzoate synthase
• EC 4.2.1.114: methanogen homoaconitase
• EC 4.2.1.115: UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting)
• EC 4.2.1.116: 3-hydroxypropionyl-CoA dehydratase
• EC 4.2.1.117: 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
• EC 4.2.1.118: 3-dehydroshikimate dehydratase
• EC 4.2.1.119: venoyl-CoA hydratase 2
• EC 4.2.1.120: 4-hydroxybutanoyl-CoA dehydratase
• EC 4.2.1.121: colneleate synthase
• EC 4.2.1.122: tryptophan synthase (indole-salvaging)
• EC 4.2.1.123: tetrahymanol synthase
• EC 4.2.1.124: arabidiol synthase
• EC 4.2.1.125: dammarenediol II synthase
• EC 4.2.1.126: N-acetylmuramic acid 6-phosphate etherase
• EC 4.2.1.127: linalool dehydratase
• EC 4.2.1.128: lupan-3beta,20-diol synthase
• EC 4.2.1.129: squalene---hopanol cyclase
• EC 4.2.1.130: D-lactate dehydratase
• EC 4.2.1.131: carotenoid 1,2-hydratase
• EC 4.2.1.132: 2-hydroxyhexa-2,4-dienoate hydratase
• EC 4.2.1.133: copal-8-ol diphosphate hydratase
• EC 4.2.1.134: very-long-chain (3R)-3-hydroxyacyl-(acyl-carrier protein) dehydratase
• EC 4.2.1.135: UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)
• EC 4.2.1.136: ADP-dependent NAD(P)H-hydrate dehydratase
• EC 4.2.1.137: sporulenol synthase
• EC 4.2.1.138: (+)-Caryolan-1-ol synthase

EC 4.2.2: Acting on Polysaccharides

• EC 4.2.2.1: hyaluronate lyase
• EC 4.2.2.2: pectate lyase
• EC 4.2.2.3: poly(b-D-mannuronate) lyase
• EC 4.2.2.4: chondroitin ABC lyase
• EC 4.2.2.5: chondroitin AC lyase
• EC 4.2.2.6: oligogalacturonide lyase
• EC 4.2.2.7: heparin lyase
• EC 4.2.2.8: heparin-sulfate lyase
• EC 4.2.2.9: pectate disaccharide-lyase
• EC 4.2.2.10: pectin lyase
• EC 4.2.2.11: poly(a-L-guluronate) lyase
• EC 4.2.2.12: xanthan lyase
• EC 4.2.2.13: exo-(1-4)-α-D-glucan lyase
• EC 4.2.2.14: glucuronan lyase
• EC 4.2.2.15: anhydrosialidase
• EC 4.2.2.16: levan fructotransferase (DFA-IV-forming)
• EC 4.2.2.17: inulin fructotransferase (DFA-I-forming)
• EC 4.2.2.18: inulin fructotransferase (DFA-III-forming)
• EC 4.2.2.19: chondroitin B lyase
• EC 4.2.2.20: chondroitin-sulfate-ABC endolyase
• EC 4.2.2.21: chondroitin-sulfate-ABC exolyase
• EC 4.2.2.22: pectate trisaccharide-lyase
• EC 4.2.2.23: rhamnogalacturonan endolyase
• EC 4.2.2.24: rhamnogalacturonan exolyase
• EC 4.2.2.25: gellan lyase

EC 4.2.3: Acting on phosphates

• EC 4.2.3.1: threonine synthase
• EC 4.2.3.2: ethanolamine-phosphate phospho-lyase
• EC 4.2.3.3: methylglyoxal synthase
• EC 4.2.3.4: 3-dehydroquinate synthase
• EC 4.2.3.5: chorismate synthase
• EC 4.2.3.6: trichodiene synthase
• EC 4.2.3.7: pentalenene synthase
• EC 4.2.3.8: casbene synthase
• EC 4.2.3.9: aristolochene synthase
• EC 4.2.3.10: (-)-endo-fenchol synthase
• EC 4.2.3.11: sabinene-hydrate synthase
• EC 4.2.3.12: 6-pyruvoyltetrahydropterin synthase
• EC 4.2.3.13: (+)-d-cadinene synthase
• EC 4.2.3.14: pinene synthase
• EC 4.2.3.15: myrcene synthase
• EC 4.2.3.16: (4S)-limonene synthase
• EC 4.2.3.17: taxadiene synthase
• EC 4.2.3.18: abietadiene synthase
• EC 4.2.3.19: ent-kaurene synthase
• EC 4.2.3.20: (R)-limonene synthase
• EC 4.2.3.21: vetispiradiene synthase
• EC 4.2.3.22: germacradienol synthase
• EC 4.2.3.23: germacrene-A synthase
• EC 4.2.3.24: amorpha-4,11-diene synthase
• EC 4.2.3.25: S-linalool synthase
• EC 4.2.3.26: R-linalool synthase
• EC 4.2.3.27: isoprene synthase
• EC 4.2.3.28: ent-cassa-12,15-diene synthase
• EC 4.2.3.29: ent-sandaracopimaradiene synthase
• EC 4.2.3.30: ent-pimara-8(14),15-diene synthase
• EC 4.2.3.31: ent-pimara-9(11),15-diene synthase
• EC 4.2.3.32: levopimaradiene synthase
• EC 4.2.3.33: stemar-13-ene synthase
• EC 4.2.3.34: stemod-13(17)-ene synthase
• EC 4.2.3.35: syn-pimara-7,15-diene synthase
• EC 4.2.3.36: terpentetriene synthase
• EC 4.2.3.37: epi-isozizaene synthase
• EC 4.2.3.38: alpha-bisabolene synthase
• EC 4.2.3.39: epi-cedrol synthase
• EC 4.2.3.40: (Z)-gamma-bisabolene synthase
• EC 4.2.3.41: elisabethatriene synthase
• EC 4.2.3.42: aphidicolan-16beta-ol synthase
• EC 4.2.3.43: fusicocca-2,10(14)-diene synthase
• EC 4.2.3.44: isopimara-7,15-diene synthase
• EC 4.2.3.45: phyllocladan-16alpha-ol synthase
• EC 4.2.3.46: alpha-farnesene synthase
• EC 4.2.3.47: beta-farnesene synthase
• EC 4.2.3.48: (3S,6E)-nerolidol synthase
• EC 4.2.3.49: (3R,6E)-nerolidol synthase
• EC 4.2.3.50: (+)-alpha-santalene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)
• EC 4.2.3.51: beta-phellandrene synthase (neryl-diphosphate-cyclizing)
• EC 4.2.3.52: (4S)-beta-phellandrene synthase (geranyl-diphosphate-cyclizing)
• EC 4.2.3.53: (+)-endo-beta-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)
• EC 4.2.3.54: (-)-endo-alpha-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)
• EC 4.2.3.55: (S)-beta-bisabolene synthase
• EC 4.2.3.56: gamma-humulene synthase
• EC 4.2.3.57: (-)-beta-caryophyllene synthase
• EC 4.2.3.58: longifolene synthase
• EC 4.2.3.59: (E)-gamma-bisabolene synthase
• EC 4.2.3.60: germacrene C synthase
• EC 4.2.3.61: 5-epiaristolochene synthase
• EC 4.2.3.62: (-)-gamma-cadinene synthase ((2Z,6E)-farnesyl diphosphate cyclizing)
• EC 4.2.3.63: (+)-cubenene synthase
• EC 4.2.3.64: (+)-epicubenol synthase
• EC 4.2.3.65: zingiberene synthase
• EC 4.2.3.66: beta-selinene cyclase
• EC 4.2.3.67: cis-muuroladiene synthase
• EC 4.2.3.68: beta-eudesmol synthase
• EC 4.2.3.69: (+)-alpha-barbatene synthase
• EC 4.2.3.70: patchoulol synthase
• EC 4.2.3.71: (E,E)-germacrene B synthase
• EC 4.2.3.72: alpha-gurjunene synthase
• EC 4.2.3.73: valencene synthase
• EC 4.2.3.74: presilphiperfolanol synthase
• EC 4.2.3.75: (-)-germacrene D synthase
• EC 4.2.3.76: (+)-delta-selinene synthase
• EC 4.2.3.77: (+)-germacrene D synthase
• EC 4.2.3.78: beta-chamigrene synthase
• EC 4.2.3.79: thujopsene synthase
• EC 4.2.3.80: alpha-longipinene synthase
• EC 4.2.3.81: exo-alpha-bergamotene synthase
• EC 4.2.3.82: alpha-santalene synthase
• EC 4.2.3.83: beta-santalene synthase
• EC 4.2.3.84: 10-epi-gamma-eudesmol synthase
• EC 4.2.3.85: alpha-eudesmol synthase
• EC 4.2.3.86: 7-epi-alpha-selinene synthase
• EC 4.2.3.87: alpha-guaiene synthase
• EC 4.2.3.88: viridiflorene synthase
• EC 4.2.3.89: (+)-beta-caryophyllene synthase
• EC 4.2.3.90: 5-epi-alpha-selinene synthase
• EC 4.2.3.91: cubebol synthase
• EC 4.2.3.92: (+)-gamma-cadinene synthase
• EC 4.2.3.93: delta-guaiene synthase
• EC 4.2.3.94: gamma-curcumene synthase
• EC 4.2.3.95: (-)-alpha-cuprenene synthase
• EC 4.2.3.96: avermitilol synthase
• EC 4.2.3.97: (-)-delta-cadinene synthase
• EC 4.2.3.98: (+)-T-muurolol synthase
• EC 4.2.3.99: labdatriene synthase
• EC 4.2.3.100: bicyclogermacrene synthase
• EC 4.2.3.101: 7-epi-sesquithujene synthase
• EC 4.2.3.102: sesquithujene synthase
• EC 4.2.3.103: ent-isokaurene synthase
• EC 4.2.3.104: alpha-humulene synthase
• EC 4.2.3.105: tricyclene synthase
• EC 4.2.3.106: (E)-beta-ocimene synthase
• EC 4.2.3.107: (+)-car-3-ene synthase
• EC 4.2.3.108: 1,8-cineole synthase
• EC 4.2.3.109: (-)-sabinene synthase
• EC 4.2.3.110: (+)-sabinene synthase
• EC 4.2.3.111: (-)-alpha-terpineol synthase
• EC 4.2.3.112: (+)-alpha-terpineol synthase
• EC 4.2.3.113: terpinolene synthase
• EC 4.2.3.114: gamma-terpinene synthase
• EC 4.2.3.115: alpha-terpinene synthase
• EC 4.2.3.116: (+)-camphene synthase
• EC 4.2.3.117: (-)-camphene synthase
• EC 4.2.3.118: 2-methylisoborneol synthase
• EC 4.2.3.119: (-)-alpha-pinene synthase
• EC 4.2.3.120: (-)-beta-pinene synthase
• EC 4.2.3.121: (+)-alpha-pinene synthase
• EC 4.2.3.122: (+)-beta-pinene synthase
• EC 4.2.3.123: beta-sesquiphellandrene synthase
• EC 4.2.3.124: 2-deoxy-scyllo-inosose synthase
• EC 4.2.3.125: alpha-muurolene synthase
• EC 4.2.3.126: gamma-muurolene synthase
• EC 4.2.3.127: beta-copaene synthase
• EC 4.2.3.128: beta-cubebene synthase
• EC 4.2.3.129: (+)-sativene synthase
• EC 4.2.3.130: tetraprenyl-beta-curcumene synthase
• EC 4.2.3.131: miltiradiene synthase
• EC 4.2.3.132: neoabietadiene synthase
• EC 4.2.3.133: alpha-copaene synthase
• EC 4.2.3.134: 5-phosphonooxy-L-lysine phospho-lyase
• EC 4.2.3.135: Delta6-protoilludene synthase
• EC 4.2.3.136: alpha-isocomene synthase
• EC 4.2.3.137: (E)-2-epi-beta-caryophyllene synthase
• EC 4.2.3.138: (+)-epi-alpha-bisabolol synthase
• EC 4.2.3.139: valerena-4,7(11)-diene synthase
• EC 4.2.3.140: cis-abienol synthase

EC 4.2.99: Other Carbon-Oxygen Lyases

• EC 4.2.99.1: now EC 4.2.2.2
• EC 4.2.99.2: now EC 4.2.3.1
• EC 4.2.99.3: now EC 4.2.2.2
• EC 4.2.99.4: now EC 4.2.2.3
• EC 4.2.99.5: deleted
• EC 4.2.99.6: deleted, included in EC 4.2.2.4 and EC 4.2.2.5
• EC 4.2.99.7: now EC 4.2.3.2
• EC 4.2.99.8: now EC 2.5.1.47
• EC 4.2.99.9: now EC 2.5.1.48
• EC 4.2.99.10: now EC 2.5.1.49
• EC 4.2.99.11: now EC 4.2.3.3
• EC 4.2.99.12: carboxymethyloxysuccinate lyase
• EC 4.2.99.13: now EC 2.5.1.50
• EC 4.2.99.14: now EC 2.5.1.51
• EC 4.2.99.15: now EC 2.5.1.52
• EC 4.2.99.16: now EC 2.5.1.53
• EC 4.2.99.17: now EC 4.2.99.14
• EC 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase
• EC 4.2.99.19: transferred entry, now EC 4.4.1.23
• EC 4.2.99.20: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
• EC 4.2.99.21: isochorismate lyase

EC 4.3: Carbon-Nitrogen Lyases

EC 4.3.1: Ammonia-Lyases

• EC 4.3.1.1: aspartate ammonia-lyase
• EC 4.3.1.2: methylaspartate ammonia-lyase
• EC 4.3.1.3: histidine ammonia-lyase
• EC 4.3.1.4: formiminotetrahydrofolate cyclodeaminase
• EC 4.3.1.5: Now divided into EC 4.3.1.23 (tyrosine ammonia-lyase), EC 4.3.1.24 (phenylalanine ammonia-lyase) and EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase)
• EC 4.3.1.6: b-alanyl-CoA ammonia-lyase
• EC 4.3.1.7: ethanolamine ammonia-lyase
• EC 4.3.1.8: now EC 2.5.1.61
• EC 4.3.1.9: glucosaminate ammonia-lyase
• EC 4.3.1.10: serine-sulfate ammonia-lyase
• EC 4.3.1.11: dihydroxyphenylalanine ammonia-lyase
• EC 4.3.1.12: ornithine cyclodeaminase
• EC 4.3.1.13: carbamoyl-serine ammonia-lyase
• EC 4.3.1.14: 3-aminobutyryl-CoA ammonia-lyase
• EC 4.3.1.15: diaminopropionate ammonia-lyase
• EC 4.3.1.16: threo-3-hydroxyaspartate ammonia-lyase
• EC 4.3.1.17: L-serine ammonia-lyase
• EC 4.3.1.18: D-serine ammonia-lyase
• EC 4.3.1.19: threonine ammonia-lyase
• EC 4.3.1.20: erythro-3-hydroxyaspartate ammonia-lyase
• EC 4.3.1.21: Identical to EC 4.3.1.9
• EC 4.3.1.22: 3,4-dihydroxyphenylalanine reductive deaminase
• EC 4.3.1.23: tyrosine ammonia-lyase
• EC 4.3.1.24: phenylalanine ammonia-lyase
• EC 4.3.1.25: phenylalanine/tyrosine ammonia-lyase
• EC 4.3.1.26: chromopyrrolate synthase is now EC 1.21.3.9, dichlorochromopyrrolate synthase
• EC 4.3.1.27: threo-3-hydroxy-D-aspartate ammonia-lyase
• EC 4.3.1.28: L-lysine cyclodeaminase

EC 4.3.2: Amidine-Lyases

• EC 4.3.2.1: argininosuccinate lyase
• EC 4.3.2.2: adenylosuccinate lyase
• EC 4.3.2.3: ureidoglycolate lyase
• EC 4.3.2.4: purine imidazole-ring cyclase
• EC 4.3.2.5: peptidylamidoglycolate lyase
• EC 4.3.2.6: gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase

EC 4.3.3: Amine-Lyases

• EC 4.3.3.1: 3-ketovalidoxylamine C-N-lyase
• EC 4.3.3.2: strictosidine synthase
• EC 4.3.3.3: deacetylisoipecoside synthase
• EC 4.3.3.4: deacetylipecoside synthase
• EC 4.3.3.5: 4'-demethylrebeccamycin synthase
• EC 4.3.3.6: pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)
• EC 4.3.3.7: 4-hydroxy-tetrahydrodipicolinate synthase

EC 4.3.99: Other Carbon-Nitrogen Lyases

• EC 4.3.99.1: now EC 4.2.1.104
• EC 4.3.99.2: carboxybiotin decarboxylase
• EC 4.3.99.3: 7-carboxy-7-deazaguanine synthase

EC 4.4: Carbon-Sulfur Lyases

• EC 4.4.1.1: cystathionine g-lyase
• EC 4.4.1.2: homocysteine desulfhydrase
• EC 4.4.1.3: dimethylpropiothetin dethiomethylase
• EC 4.4.1.4: alliin lyase
• EC 4.4.1.5: lactoylglutathione lyase
• EC 4.4.1.6: S-alkylcysteine lyase
• EC 4.4.1.7: deleted, included in EC 2.5.1.18
• EC 4.4.1.8: cystathionine b-lyase
• EC 4.4.1.9: L-3-cyanoalanine synthase
• EC 4.4.1.10: cysteine lyase
• EC 4.4.1.11: methionine g-lyase
• EC 4.4.1.12: deleted
• EC 4.4.1.13: cysteine-S-conjugate b-lyase
• EC 4.4.1.14: 1-aminocyclopropane-1-carboxylate synthase
• EC 4.4.1.15: D-cysteine desulfhydrase
• EC 4.4.1.16: selenocysteine lyase
• EC 4.4.1.17: holocytochrome-c synthase
• EC 4.4.1.18: now EC 1.8.3.5
• EC 4.4.1.19: phosphosulfolactate synthase
• EC 4.4.1.20: leukotriene-C4 synthase
• EC 4.4.1.21: S-ribosylhomocysteine lyase
• EC 4.4.1.22: S-(hydroxymethyl)glutathione synthase
• EC 4.4.1.23: 2-hydroxypropyl-CoM lyase
• EC 4.4.1.24: (2R)-sulfolactate sulfo-lyase
• EC 4.4.1.25: L-cysteate sulfo-lyase
• EC 4.4.1.26: olivetolic acid cyclase

EC 4.5: Carbon-Halide Lyases

• EC 4.5.1.1: DDT-dehydrochlorinase
• EC 4.5.1.2: 3-chloro-D-alanine dehydrochlorinase
• EC 4.5.1.3: dichloromethane dehalogenase
• EC 4.5.1.4: L-2-amino-4-chloropent-4-enoate dehydrochlorinase
• EC 4.5.1.5: S-carboxymethylcysteine synthase

EC 4.6: Phosphorus-Oxygen Lyases

• EC 4.6.1.1: adenylate cyclase
• EC 4.6.1.2: guanylate cyclase
• EC 4.6.1.3: now EC 4.2.3.4
• EC 4.6.1.4: now EC 4.2.3.5
• EC 4.6.1.5: now EC 4.2.3.7
• EC 4.6.1.6: cytidylate cyclase
• EC 4.6.1.7: now EC 4.2.3.8
• EC 4.6.1.8: now EC 4.2.3.10
• EC 4.6.1.9: now EC 4.2.3.11
• EC 4.6.1.10: now EC 4.2.3.12
• EC 4.6.1.11: now EC 4.2.3.13
• EC 4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
• EC 4.6.1.13: phosphatidylinositol diacylglycerol-lyase
• EC 4.6.1.14: glycosylphosphatidylinositol diacylglycerol-lyase
• EC 4.6.1.15: FAD-AMP lyase (cyclizing)
• EC 4.6.1.16: TRNA-intron endonuclease

EC 4.99: Other Lyases

• EC 4.99.1.1: ferrochelatase
• EC 4.99.1.2: alkylmercury lyase
• EC 4.99.1.3: sirohydrochlorin cobaltochelatase
• EC 4.99.1.4: sirohydrochlorin ferrochelatase
• EC 4.99.1.5: aliphatic aldoxime dehydratase
• EC 4.99.1.6: indoleacetaldoxime dehydratase
• EC 4.99.1.7: phenylacetaldoxime dehydratase
• EC 4.99.1.8: heme ligase

References

1. http://www.genome.jp/dbget-bin/www_bget?ec:4.1.2.8
2. http://www.ebi.ac.uk/intenz/query?cmd=SearchEC&ec=4.1.2.8