- Alan Preston (born 1932), New Zealand soccer player
- Alex Preston (born 1979), British writer
- Allan Preston (born 1969), Scottish footballer
- Andrej Preston, Slovenian internet personality
- Andrew Preston (1846–1924), American businessman
- Andy Preston (born 1957), Australian rules footballer
- Ann Preston (1813–1872), American doctor and educator
- Anthony Preston (disambiguation), multiple people
- Antony Preston (1938–2004), English naval historian
- Arthur Preston (disambiguation), multiple people
- Benjamin Preston (1846–1914), English cricketer
- Billy Preston (1946–2006), American musician
- Bob Preston, Scottish footballer
- Brian Preston (born 1958), Australian judge
- Carl Preston (born 1991), English footballer
- Carrie Preston (born 1967), American actress
- Chanel Preston (born 1985), American actress
- Charles Preston (c.1735–1800), British Major
- Cheryl B. Preston, American lawyer
- Cynthia Preston (born 1968), Canadian actress
- Dan Preston (born 1991), English footballer
- Dave Preston (disambiguation), multiple people
- Denis Preston (1916–1979), British record producer and music critic
- Don Preston (born 1932), American musician
- Don Preston (guitarist), American musician
- Douglas Preston (born 1956), American author
- Duke Preston (born 1982), American football player
- Duncan Preston (born 1946), British actor
- Eddie Preston (1925–2009), American musician
- Edward Preston (1831–1890), lawyer and judge in Hawaii
- Edward Carter Preston (1885–1965), English artist
- Frances Folsom Cleveland Preston (1864–1947), first lady of the United States
- Francis Preston (1765–1836), American lawyer and politician
- Frank W. Preston (1896–1989), American ecologist, engineer, and conservationist
- Gaylene Preston, New Zealand film director
- Gerry Preston, New Zealand boxing trainer
- Gordon Preston (born 1925), English mathematician
- Harry Preston (disambiguation), multiple people
- Henry Preston (disambiguation), multiple people
- Herbert Irving Preston (1876–1928), American Medal of Honor recipient
- Hubert Preston (1868–1960), British journalist
- J.A. Preston, American actor
- Jacob Alexander Preston (1796–1868), American politician
- James Preston (disambiguation), multiple people
- Jean R. Preston, American politician
- Jenico Preston, 14th Viscount Gormanston (1837–1907)
- Jenico Preston, 17th Viscount Gormanston (born 1939)
- Jimmy Preston (1913–1984), American musician
- John Preston (disambiguation), multiple people
- Johnny Preston (1939–2011), American singer
- Joseph Preston (disambiguation), multiple people
- Josiah Preston (1885–unknown), English footballer
- Josiah Johnston Preston (1855–1937), Canadian businessman and politician
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- June Preston (born 1928), American actress and singer
- Karen Preston (born 1971), Canadian figure skater
- Keith Preston
- Kelly Preston (born 1962), American actress
- Kenneth Preston (born 1957), American soldier
- Kiki Preston (1898–1946), American socialite
- Lewis Preston (disambiguation), multiple people
- Lionel Preston (1875–1971), Royal Navy officer
- Louisa Preston (born 1978), British journalist
- Luke Preston (born 1976), Welsh judoka
- Margaret Preston (1875–1963), Australian artist
- Margaret Junkin Preston (1820–1897), American poet and author
- Mark Preston
- Matt Preston (born 1961), Australian journalist
- Maurice A. Preston (1912–1983), United States Air Force general
- Michael Preston (disambiguation), multiple people
- Natalie Preston (born 1977), English footballer
- Nigel Preston (1959–1992), British musician
- Noel Preston, ethicist, theologian and social commentator
- Norman Preston (1903–1980), English cricket journalist
- Paschal Preston, Irish academic
- Paul Preston (born 1946), British historian
- Peter Preston (born 1938), British journalist
- Peter Preston (born 1935), Canadian politician
- Platt A. Preston (1837–1900), American politician
- Prince Hulon Preston, Jr. (1908–1961), American politician, educator and lawyer
- Rachel Oakes Preston (1809–1868), member of Seventh-day Adventist Church
- Ray Preston (disambiguation), multiple people
- Reg Preston (1917–2000), Australian potter
- Rich Preston (born 1952), Canadian ice hockey player
- Richard Preston (born 1954), American author
- Richard Preston (clergyman) (1791–1861), American religious leader
- Richard Franklin Preston (1860–1929), Canadian physician and politician
- Rob Preston (born 1982), American basketball player
- Robert Preston (disambiguation), multiple people
- Roell Preston (born 1972), American football player
- Ron Preston (born 1958), American speedway rider
- Sally Preston (born 1964), British entrepreneur
- Samuel Preston (disambiguation), multiple people including:
- Sarah Preston (born 1970), English actress
- Shelley Preston (born 1964), English singer
- Simon Preston (born 1938), British organist and composer
- Stephen Preston (disambiguation), multiple people
- Steve Preston (born 1960), American businessman and civil servant
- Thomas Preston (disambiguation), multiple people
- Tommy Preston, Scottish footballer
- Walt Preston (1868–1937), American baseball player
- Walter Preston (disambiguation), multiple people
- Ward Preston, American production designer and art director
- Wayde Preston (1929–1992), American actor
- William Preston (disambiguation), multiple people
- Yves Preston (born 1956), Canadian ice hockey player
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