MEX3D

MEX3D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DGR
Identifiers
Aliases	MEX3D, MEX-3D, MEX3, OK/SW-cl.4, RKHD1, RNF193, TINO, mex-3 RNA binding family member D
External IDs	MGI: 2681847 HomoloGene: 16890 GeneCards: MEX3D
Gene ontology Molecular function • poly(A) RNA binding • zinc ion binding • AU-rich element binding • metal ion binding • RNA binding • nucleic acid binding Cellular component • cytoplasm • perinuclear region of cytoplasm • nucleus Biological process • mRNA destabilization • mRNA localization resulting in posttranscriptional regulation of gene expression Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	399664	237400
Ensembl	ENSG00000181588	ENSMUSG00000048696
UniProt	Q86XN8	Q3UE17
RefSeq (mRNA)	NM_001174118 NM_203304	NM_198615
RefSeq (protein)	NP_001167589.1 NP_976049.3	NP_941017.2
Location (UCSC)	Chr 19: 1.55 – 1.57 Mb	Chr 10: 80.38 – 80.39 Mb
PubMed search	[1]	[2]
Wikidata

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Mex-3 homolog D (C. elegans), also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene.^[3][4]

Function

MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.^[4]

Structure

MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs ( KH domain ) and a RING domain at the C-terminus.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: mex-3 homolog D (C. elegans)".
4. Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154–66. doi:10.1074/jbc.M314071200. PMID 14769789.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Buchet-Poyau K, Courchet J, Le Hir H, et al. (2007). "Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.". Nucleic Acids Res. 35 (4): 1289–300. doi:10.1093/nar/gkm016. PMC 1851655. PMID 17267406.