MIB2 (gene)

MIB2
Identifiers
Aliases	MIB2, ZZANK1, ZZZ5, mindbomb E3 ubiquitin protein ligase 2
External IDs	MGI: 2679684 HomoloGene: 16062 GeneCards: MIB2
Gene ontology Molecular function • signal transducer activity • zinc ion binding • ubiquitin protein ligase activity • metal ion binding • ligase activity • actin binding • protein binding • ubiquitin-protein transferase activity Cellular component • cytoplasm • endosome • early endosome • ubiquitin ligase complex • cytosol Biological process • Notch signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • protein ubiquitination • protein polyubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	142678	76580
Ensembl	ENSG00000197530	ENSMUSG00000029060
UniProt	Q96AX9	Q8R516
RefSeq (mRNA)	NM_001170686 NM_001170687 NM_001170688 NM_001170689 NM_080875	NM_001256107 NM_001256108 NM_001256110 NM_145124
RefSeq (protein)	NP_001164157.1 NP_001164158.1 NP_001164159.1 NP_001164160.1 NP_543151.2	NP_001243037.2 NP_660106.2
Location (UCSC)	Chr 1: 1.62 – 1.63 Mb	Chr 4: 155.65 – 155.67 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

E3 ubiquitin-protein ligase MIB2 is an enzyme that in humans is encoded by the MIB2 gene.^[3][4]

Interactions

MIB2 (gene) has been shown to interact with Actin, alpha 1.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
4. "Entrez Gene: MIB2 mindbomb homolog 2 (Drosophila)".
5. Takeuchi, Tamotsu; Heng Henry H Q; Ye Christine J; Liang Sheng-Ben; Iwata Jun; Sonobe Hiroshi; Ohtsuki Yuji (Oct 2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. United States. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. ISSN 0002-9440. PMC 1868282. PMID 14507647.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takeuchi T, Heng HH, Ye CJ, et al. (2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma.". Am. J. Pathol. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. PMC 1868282. PMID 14507647.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Koo BK, Yoon KJ, Yoo KW, et al. (2005). "Mind bomb-2 is an E3 ligase for Notch ligand.". J. Biol. Chem. 280 (23): 22335–42. doi:10.1074/jbc.M501631200. PMID 15824097.
• Takeuchi T, Adachi Y, Ohtsuki Y (2005). "Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma.". DNA Cell Biol. 24 (5): 339–44. doi:10.1089/dna.2005.24.339. PMID 15869411.
• Takeuchi T, Adachi Y, Ohtsuki Y (2005). "Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma.". Am. J. Pathol. 166 (6): 1817–26. doi:10.1016/S0002-9440(10)62491-1. PMC 1602431. PMID 15920166.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Takeuchi T, Adachi Y, Sonobe H, et al. (2006). "A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion.". Oncogene. 25 (53): 7059–69. doi:10.1038/sj.onc.1209688. PMID 16715130.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.