MKL2

MKL2
Identifiers
Aliases	MKL2, MRTF-B, MRTFB, NPD001, MKL1/myocardin like 2
External IDs	MGI: 3050795 HomoloGene: 40917 GeneCards: MKL2
Gene ontology Molecular function • transcription coactivator activity • RNA polymerase II transcription coactivator activity • protein binding • cadherin binding involved in cell-cell adhesion Cellular component • cell-cell adherens junction • nucleus Biological process • multicellular organism development • muscle organ development • regulation of transcription, DNA-templated • smooth muscle cell differentiation • positive regulation of striated muscle tissue development • positive regulation of transcription from RNA polymerase II promoter • cell differentiation • transcription, DNA-templated • cell-cell adhesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57496	239719
Ensembl	ENSG00000186260	ENSMUSG00000009569
UniProt	Q9ULH7	P59759
RefSeq (mRNA)	NM_001308142 NM_014048	NM_001122667 NM_153588 NM_181860
RefSeq (protein)	NP_001295071.1 NP_054767.3	NP_705816.2
Location (UCSC)	Chr 16: 14.07 – 14.27 Mb	Chr 16: 13.26 – 13.42 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

MKL/myocardin-like protein 2 is a protein that in humans is encoded by the MKL2 gene.^[3][4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
4. "Entrez Gene: MKL2 MKL/myocardin-like 2".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Wang DZ, Li S, Hockemeyer D, et al. (2003). "Potentiation of serum response factor activity by a family of myocardin-related transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 99 (23): 14855–60. doi:10.1073/pnas.222561499. PMC 137508. PMID 12397177.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cen B, Selvaraj A, Burgess RC, et al. (2003). "Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes.". Mol. Cell. Biol. 23 (18): 6597–608. doi:10.1128/MCB.23.18.6597-6608.2003. PMC 193697. PMID 12944485.
• Selvaraj A, Prywes R (2004). "Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation.". J. Biol. Chem. 278 (43): 41977–87. doi:10.1074/jbc.M305679200. PMID 14565952.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Morita T, Mayanagi T, Sobue K (2007). "Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling.". J. Cell Biol. 179 (5): 1027–42. doi:10.1083/jcb.200708174. PMC 2099179. PMID 18056415.