Myomegalin

PDE4DIP
Identifiers
Aliases	PDE4DIP, CMYA2, MMGL, phosphodiesterase 4D interacting protein
External IDs	MGI: 1891434 HomoloGene: 66961 GeneCards: PDE4DIP
Gene ontology Molecular function • enzyme binding • protein binding Cellular component • Golgi apparatus • myofibril • nucleus • cytoplasm • microtubule organizing center • cytoskeleton • centrosome Biological process • cellular protein complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9659	83679
Ensembl	ENSG00000178104	ENSMUSG00000038170
UniProt	Q5VU43	Q80YT7
RefSeq (mRNA)	NM_001002810 NM_001002811 NM_001002812 NM_001195260 NM_001195261 NM_001198832 NM_001198834 NM_014644 NM_022359	NM_001039376 NM_001110163 NM_001289701 NM_001289702 NM_031401 NM_177145 NM_178080
RefSeq (protein)	NP_001002810.1 NP_001002811.2 NP_001002812.2 NP_001182189.1 NP_001182190.1 NP_001185761.2 NP_001185763.3 NP_055459.5 NP_071754.3	NP_001034465.2 NP_835181.2
Location (UCSC)	Chr 1: 148.81 – 149.05 Mb	Chr 3: 97.69 – 97.89 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Myomegalin also known as phosphodiesterase 4D-interacting protein or cardiomyopathy-associated protein 2 is a protein that in humans is encoded by the PDE4DIP gene.^[3][4][5]

Interactions

PDE4DIP has been shown to interact with PDE4D.^[4]

Related gene problems

• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
4. Verde I, Pahlke G, Salanova M, Zhang G, Wang S, Coletti D, Onuffer J, Jin SL, Conti M (Apr 2001). "Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase". J Biol Chem. 276 (14): 11189–98. doi:10.1074/jbc.M006546200. PMID 11134006.
5. "Entrez Gene: PDE4DIP phosphodiesterase 4D interacting protein (myomegalin)".

Further reading

• Soejima H, Kawamoto S, Akai J, et al. (2001). "Isolation of novel heart-specific genes using the BodyMap database.". Genomics. 74 (1): 115–20. doi:10.1006/geno.2001.6527. PMID 11374908.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Okazaki N, Kikuno R, Ohara R, et al. (2003). "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.". DNA Res. 10 (1): 35–48. doi:10.1093/dnares/10.1.35. PMID 12693553.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Shimada H, Kuboshima M, Shiratori T, et al. (2007). "Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma.". Int. J. Oncol. 30 (1): 97–103. doi:10.3892/ijo.30.1.97. PMID 17143517.