NDUFC2

NDUFC2
Identifiers
Aliases	NDUFC2, B14.5b, CI-B14.5b, HLC-1, NADHDH2, NADH:ubiquinone oxidoreductase subunit C2
External IDs	MGI: 1344370 HomoloGene: 3344 GeneCards: NDUFC2
Gene ontology Molecular function • NADH dehydrogenase (ubiquinone) activity Cellular component • cytoplasm • integral component of membrane • mitochondrial inner membrane • mitochondrial respiratory chain complex I • respiratory chain • membrane • mitochondrion Biological process • oxidation-reduction process • mitochondrial respiratory chain complex I assembly • mitochondrial electron transport, NADH to ubiquinone Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4718	68197
Ensembl	ENSG00000151366	ENSMUSG00000030647
UniProt	O95298	Q9CQ54
RefSeq (mRNA)	NM_004549 NM_001204054 NM_001204055	NM_024220
RefSeq (protein)	NP_001190983.1 NP_001190984.1 NP_004540.1	NP_077182.1
Location (UCSC)	Chr 11: 78.07 – 78.08 Mb	Chr 7: 97.4 – 97.41 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

NADH dehydrogenase [ubiquinone] 1 subunit C2 is an enzyme that in humans is encoded by the NDUFC2 gene.^[3][4]

The NDUF2 gene encodes one of the subunits of complex I, the first and largest complex of the mitochondrial respiratory chain.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Loeffen JL, Triepels RH, van den Heuvel LP, Schuelke M, Buskens CA, Smeets RJ, Trijbels JM, Smeitink JA (Jan 1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed". Biochem Biophys Res Commun. 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
4. "Entrez Gene: NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa".

Further reading

• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.