NEK1

NEK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4APC, 4B9D
Identifiers
Aliases	NEK1, NY-REN-55, SRPS2, SRPS2A, SRTD6, NIMA related kinase 1
External IDs	MGI: 97303 HomoloGene: 14376 GeneCards: NEK1
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • metal ion binding • kinase activity • protein binding • protein tyrosine kinase activity • ATP binding • protein serine/threonine kinase activity • signal transducer, downstream of receptor, with serine/threonine kinase activity Cellular component • cytoplasm • centrosome • pericentriolar material • microtubule organizing center • cytoskeleton • nucleus Biological process • mitotic nuclear division • phosphorylation • cell division • protein phosphorylation • cell projection organization • cilium assembly • cell cycle • peptidyl-tyrosine phosphorylation • signal transduction by protein phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4750	18004
Ensembl	ENSG00000137601	ENSMUSG00000031644
UniProt	Q96PY6	P51954
RefSeq (mRNA)	NM_001199397 NM_001199398 NM_001199399 NM_001199400 NM_012224	NM_001293637 NM_001293638 NM_001293639 NM_175089
RefSeq (protein)	NP_001186326.1 NP_001186327.1 NP_001186328.1 NP_001186329.1 NP_036356.1	NP_001280566.1 NP_001280567.1 NP_001280568.1 NP_780298.2
Location (UCSC)	Chr 4: 169.39 – 169.61 Mb	Chr 8: 60.99 – 61.13 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

NIMA (never in mitosis gene a)-related kinase 1, also known as NEK1, is a human gene highly expressed in germ cells and thought to be involved in meiosis. It is also involved in the response to DNA damage from radiation; defects in this gene can be a cause of polycystic kidney disease.^[3] NEK1 is thought to be involved in amytrophic lateral sclerosis.^[4][5]

See also

• NEK2
• NEK3
• NEK4

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "NEK1 NIMA related kinase 1 [Homo sapiens (human)] - Gene - NCBI". Retrieved 28 July 2016.
4. "Ice Bucket Challenge funds gene discovery in ALS (MND) research - BBC News". BBC. 2016-07-27. Retrieved 2016-07-27.
5. Kenna KP, van Doormaal PT, Dekker AM, Ticozzi N, Kenna BJ, Diekstra FP, et al. (July 2016). "NEK1 variants confer susceptibility to amyotrophic lateral sclerosis". Nature Genetics. doi:10.1038/ng.3626. PMID 27455347.

Further reading

• Letwin K, Mizzen L, Motro B, Ben-David Y, Bernstein A, Pawson T (October 1992). "A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells". The EMBO Journal. 11 (10): 3521–31. PMC 556810. PMID 1382974.
• Upadhya P, Birkenmeier EH, Birkenmeier CS, Barker JE (January 2000). "Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice". Proceedings of the National Academy of Sciences of the United States of America. 97 (1): 217–21. doi:10.1073/pnas.97.1.217. PMC 26643. PMID 10618398.
• Schultz SJ, Nigg EA (October 1993). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth & Differentiation. 4 (10): 821–30. PMID 8274451.
• Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (November 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
• Nagase T, Kikuno R, Ohara O (August 2001). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Research. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
• Surpili MJ, Delben TM, Kobarg J (December 2003). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
• Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (November 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Polci R, Peng A, Chen PL, Riley DJ, Chen Y (December 2004). "NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response". Cancer Research. 64 (24): 8800–3. doi:10.1158/0008-5472.CAN-04-2243. PMID 15604234.