Neurogenin-1

NEUROG1
Identifiers
Aliases	NEUROG1, AKA, Math4C, NEUROD3, bHLHa6, ngn1, neurogenin 1
External IDs	MGI: 107754 HomoloGene: 4490 GeneCards: NEUROG1
Gene ontology Molecular function • DNA binding • protein dimerization activity • transcription factor activity, transcription factor binding • transcription factor activity, sequence-specific DNA binding • chromatin binding • E-box binding • protein binding Cellular component • perikaryon • neuronal cell body • nucleus Biological process • regulation of neuron differentiation • neurogenesis • cell differentiation • cell fate commitment • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of exit from mitosis • transcription, DNA-templated • nervous system development • multicellular organism development • inner ear morphogenesis • positive regulation of neuron differentiation • neuron differentiation • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4762	18014
Ensembl	ENSG00000181965	ENSMUSG00000048904
UniProt	Q92886	P70660
RefSeq (mRNA)	NM_006161	NM_010896
RefSeq (protein)	NP_006152.2	NP_035026.1
Location (UCSC)	Chr 5: 135.53 – 135.54 Mb	Chr 13: 56.25 – 56.25 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

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Neurogenin-1 is a protein that in humans is encoded by the NEUROG1 gene.^[3][4]

Interactions

NEUROG1 has been shown to interact with CREB-binding protein^[5] and decapentaplegic homolog 1.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Mar 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics. 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405.
4. "Entrez Gene: NEUROG1 neurogenin 1".
5. Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME (Feb 2001). "Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms". Cell. 104 (3): 365–76. doi:10.1016/S0092-8674(01)00224-0. PMID 11239394.

Further reading

• McCormick MB, Tamimi RM, Snider L, Asakura A, Bergstrom D, Tapscott SJ (Oct 1996). "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family". Molecular and Cellular Biology. 16 (10): 5792–800. doi:10.1128/mcb.16.10.5792. PMC 231580. PMID 8816493.
• Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME (Feb 2001). "Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms". Cell. 104 (3): 365–76. doi:10.1016/S0092-8674(01)00224-0. PMID 11239394.
• Franklin A, Kao A, Tapscott S, Unis A (Nov 2001). "NeuroD homologue expression during cortical development in the human brain". Journal of Child Neurology. 16 (11): 849–53. doi:10.1177/08830738010160111201. PMID 11732772.
• Kim S, Ghil SH, Kim SS, Myeong HH, Lee YD, Suh-Kim H (Dec 2002). "Overexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells". Experimental & Molecular Medicine. 34 (6): 469–75. doi:10.1038/emm.2002.65. PMID 12526089.
• Fanous AH, Chen X, Wang X, Amdur RL, O'Neill FA, Walsh D, Kendler KS (Mar 2007). "Association between the 5q31.1 gene neurogenin1 and schizophrenia". American Journal of Medical Genetics Part B. 144B (2): 207–14. doi:10.1002/ajmg.b.30423. PMID 17044100.
• Liscovitch N, Chechik G (2013). "Specialization of gene expression during mouse brain development". PLoS Computational Biology. 9 (9): e1003185. doi:10.1371/journal.pcbi.1003185. PMC 3777910. PMID 24068900.