NLGN2

NLGN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BL8
Identifiers
Aliases	NLGN2
External IDs	MGI: 2681835 HomoloGene: 69317 GeneCards: NLGN2
Gene ontology Molecular function • carboxylic ester hydrolase activity • neurexin family protein binding • cell adhesion molecule binding • receptor activity Cellular component • integral component of membrane • postsynaptic membrane • membrane • plasma membrane • synapse • integral component of plasma membrane • inhibitory synapse • extracellular fluid • cell surface • cell junction • presynaptic membrane Biological process • single organismal cell-cell adhesion • neuromuscular process controlling balance • neuron cell-cell adhesion • positive regulation of inhibitory postsynaptic potential • synapse organization • modulation of synaptic transmission • positive regulation of protein localization to synapse • gephyrin clustering involved in postsynaptic density assembly • postsynaptic density protein 95 clustering • positive regulation of synaptic transmission, GABAergic • regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity • locomotory exploration behavior • regulation of respiratory gaseous exchange by neurological system process • cell-cell junction maintenance • positive regulation of synaptic vesicle clustering • positive regulation of synaptic transmission, glutamatergic • cell adhesion • positive regulation of excitatory postsynaptic potential • sensory perception of pain • terminal button organization • protein localization to synapse • positive regulation of insulin secretion • positive regulation of synapse assembly • presynaptic membrane assembly • synapse assembly • postsynaptic membrane assembly • inhibitory synapse assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57555	216856
Ensembl	ENSG00000169992	ENSMUSG00000051790
UniProt	Q8NFZ4	Q69ZK9
RefSeq (mRNA)	NM_020795	NM_198862
RefSeq (protein)	NP_065846.1	NP_942562.2
Location (UCSC)	Chr 17: 7.4 – 7.42 Mb	Chr 11: 69.82 – 69.84 Mb
PubMed search	[1]	[2]
Wikidata

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Neuroligin-2 is a protein that in humans is encoded by the NLGN2 gene.^[3][4][5]

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.
4. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
5. "Entrez Gene: NLGN2 neuroligin 2".

Further reading

• Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ...". Curr. Biol. 10 (17): R620–3. doi:10.1016/S0960-9822(00)00663-1. PMID 10996085.
• Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". J. Biol. Chem. 271 (5): 2676–82. doi:10.1074/jbc.271.5.2676. PMID 8576240.
• Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95". Science. 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID 9278515.
• Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci. 11 (3): 161–72. doi:10.1006/mcne.1998.0679. PMID 9647694.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Scheiffele P, Fan J, Choih J, et al. (2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons". Cell. 101 (6): 657–69. doi:10.1016/S0092-8674(00)80877-6. PMID 10892652.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jamain S, Quach H, Betancur C, et al. (2003). "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism". Nat. Genet. 34 (1): 27–9. doi:10.1038/ng1136. PMC 1925054. PMID 12669065.