NPW

NPW
Identifiers
Aliases	NPW, L8, L8C, PPL8, PPneuropeptide W
External IDs	MGI: 2685781 HomoloGene: 17727 GeneCards: NPW
Gene ontology Molecular function • protein binding • G-protein coupled receptor binding Cellular component • extracellular region Biological process • G-protein coupled receptor signaling pathway • neuropeptide signaling pathway • feeding behavior Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	283869	381073
Ensembl	ENSG00000183971	ENSMUSG00000071230
UniProt	Q8N729	n/a
RefSeq (mRNA)	NM_001099456	NM_001099664
RefSeq (protein)	NP_001092926.2	n/a
Location (UCSC)	Chr 16: 2.01 – 2.02 Mb	Chr 17: 24.66 – 24.66 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Neuropeptide W is a protein that in humans is encoded by the NPW gene.^[3][4][5]

Neuropeptide W (NPW) is an endogenous peptide ligand for GPR8 (MIM 600731), a G protein-coupled receptor.[supplied by OMIM]^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Fujii R, Yoshida H, Fukusumi S, Habata Y, Hosoya M, Kawamata Y, Yano T, Hinuma S, Kitada C, Asami T, Mori M, Fujisawa Y, Fujino M (Sep 2002). "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7". J Biol Chem. 277 (37): 34010–6. doi:10.1074/jbc.M205883200. PMID 12118011.
4. Brezillon S, Lannoy V, Franssen JD, Le Poul E, Dupriez V, Lucchetti J, Detheux M, Parmentier M (Jan 2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8". J Biol Chem. 278 (2): 776–83. doi:10.1074/jbc.M206396200. PMID 12401809.
5. "Entrez Gene: NPW neuropeptide W".

Further reading

• Singh G, Davenport AP (2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system.". Br. J. Pharmacol. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Shimomura Y, Harada M, Goto M, et al. (2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.". J. Biol. Chem. 277 (39): 35826–32. doi:10.1074/jbc.M205337200. PMID 12130646.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tanaka H, Yoshida T, Miyamoto N, et al. (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. doi:10.1073/pnas.0837789100. PMC 156358. PMID 12719537.
• Mondal MS, Yamaguchi H, Date Y, et al. (2003). "A role for neuropeptide W in the regulation of feeding behavior.". Endocrinology. 144 (11): 4729–33. doi:10.1210/en.2003-0536. PMID 12959997.
• Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.". J. Clin. Endocrinol. Metab. 90 (6): 3466–71. doi:10.1210/jc.2004-2132. PMID 15797961.
• Andreis PG, Rucinski M, Neri G, et al. (2006). "Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects.". Int. J. Mol. Med. 16 (6): 1021–8. doi:10.3892/ijmm.16.6.1021. PMID 16273281.
• Mondal MS, Yamaguchi H, Date Y, et al. (2006). "Neuropeptide W is present in antral G cells of rat, mouse, and human stomach.". J. Endocrinol. 188 (1): 49–57. doi:10.1677/joe.1.06195. PMID 16394174.