ORAI2

ORAI2
Identifiers
Aliases	ORAI2, C7orf19, CBCIP2, MEM142B, TMEM142B, ORAI calcium release-activated calcium modulator 2
External IDs	MGI: 2443195 HomoloGene: 32799 GeneCards: ORAI2
Gene ontology Molecular function • store-operated calcium channel activity • protein binding Cellular component • growth cone • integral component of membrane • membrane Biological process • store-operated calcium entry • calcium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80228	269717
Ensembl	ENSG00000160991	ENSMUSG00000039747
UniProt	Q96SN7	Q8BH10
RefSeq (mRNA)	NM_032831 NM_001126340 NM_001271818 NM_001271819	NM_178751
RefSeq (protein)	NP_001119812.1 NP_001258747.1 NP_116220.1	NP_848866.2
Location (UCSC)	Chr 7: 102.43 – 102.46 Mb	Chr 5: 136.15 – 136.17 Mb
PubMed search	[1]	[2]
Wikidata

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Protein orai-2 is a protein that in humans is encoded by the ORAI2 gene.^[3][4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A (May 2006). "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function". Nature. 441 (7090): 179–85. doi:10.1038/nature04702. PMID 16582901.
4. "Entrez Gene: TMEM142B transmembrane protein 142B".

Further reading

• DeHaven WI, Smyth JT, Boyles RR, Putney JW (2007). "Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels.". J. Biol. Chem. 282 (24): 17548–56. doi:10.1074/jbc.M611374200. PMID 17452328.
• Mercer JC, Dehaven WI, Smyth JT, et al. (2006). "LARGE STORE-OPERATED CALCIUM-SELECTIVE CURRENTS DUE TO CO-EXPRESSION OF ORAI1 OR ORAI2 WITH THE INTRACELLULAR CALCIUM SENSOR, STIM1". J. Biol. Chem. 281 (34): 24979–90. doi:10.1074/jbc.M604589200. PMC 1633822. PMID 16807233.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• <Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.