PCDH7

PCDH7
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2YST
Identifiers
Aliases	PCDH7, BH-Pcdh, BHPCDH, PPP1R120, protocadherin 7
External IDs	MGI: 1860487 HomoloGene: 36101 GeneCards: PCDH7
Gene ontology Molecular function • calcium ion binding Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane • platelet alpha granule membrane Biological process • cell adhesion • homophilic cell adhesion via plasma membrane adhesion molecules • platelet degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5099	54216
Ensembl	ENSG00000169851	ENSMUSG00000029108
UniProt	O60245	n/a
RefSeq (mRNA)	NM_001173523 NM_002589 NM_032456 NM_032457	NM_001122758 NM_018764 NM_001310606 NM_001310608
RefSeq (protein)	NP_002580.2 NP_115832.1	n/a
Location (UCSC)	Chr 4: 30.72 – 31.15 Mb	Chr 5: 57.72 – 58.13 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Protocadherin-7 is a protein that in humans is encoded by the PCDH7 gene.^[3][4]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a protein with an extracellular domain containing 7 cadherin repeats. The gene product is an integral membrane protein that is thought to function in cell-cell recognition and adhesion. Alternative splicing yields isoforms with unique cytoplasmic tails.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Yoshida K, Yoshitomo-Nakagawa K, Seki N, Sasaki M, Sugano S (Aug 1998). "Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily". Genomics. 49 (3): 458–61. doi:10.1006/geno.1998.5271. PMID 9615233.
4. "Entrez Gene: PCDH7 protocadherin 7".

Further reading

• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752.
• Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
• Yoshida K, Watanabe M, Kato H, et al. (1999). "BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain.". FEBS Lett. 460 (1): 93–8. doi:10.1016/S0014-5793(99)01309-5. PMID 10571067.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.