PDE11A

PDE11A
Identifiers
Aliases	PDE11A, PPNAD2, phosphodiesterase 11A
External IDs	MGI: 3036251 HomoloGene: 56763 GeneCards: PDE11A
Targeted by Drug
tadalafil[1]
Gene ontology Molecular function • phosphoric diester hydrolase activity • cyclic-nucleotide phosphodiesterase activity • cAMP binding • cGMP binding • catalytic activity • 3',5'-cyclic-nucleotide phosphodiesterase activity • hydrolase activity • metal ion binding • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity • 3',5'-cyclic-AMP phosphodiesterase activity • 3',5'-cyclic-GMP phosphodiesterase activity Cellular component • cytoplasm • cytosol • perikaryon • cellular component Biological process • metabolic process • cAMP catabolic process • signal transduction • cGMP catabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50940	241489
Ensembl	ENSG00000128655	ENSMUSG00000075270
UniProt	Q9HCR9	P0C1Q2
RefSeq (mRNA)	NM_016953 NM_001077196 NM_001077197 NM_001077358	NM_001081033
RefSeq (protein)	NP_001070664.1 NP_001070665.1 NP_001070826.1 NP_058649.3	NP_001074502.1
Location (UCSC)	Chr 2: 177.62 – 178.11 Mb	Chr 2: 75.99 – 76.34 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.^[4][5]

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.^[5]

Inhibitors

• BC11-38 ^[6]

References

1. "Drugs that physically interact with Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC (Apr 2000). "Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A". Proc Natl Acad Sci U S A. 97 (7): 3702–7. doi:10.1073/pnas.050585197. PMC 16303. PMID 10725373.
5. "Entrez Gene: PDE11A phosphodiesterase 11A".
6. Ceyhan O, Birsoy K, Hoffman CS (2012). "Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen". Chem. Biol. 19 (1): 155–63. doi:10.1016/j.chembiol.2011.12.010. PMID 22284362.

Further reading

• Beavo JA, Conti M, Heaslip RJ (1994). "Multiple cyclic nucleotide phosphodiesterases.". Mol. Pharmacol. 46 (3): 399–405. PMID 7935318.
• "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Yuasa K, Kotera J, Fujishige K, et al. (2000). "Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression.". J. Biol. Chem. 275 (40): 31469–79. doi:10.1074/jbc.M003041200. PMID 10906126.
• Hetman JM, Robas N, Baxendale R, et al. (2001). "Cloning and characterization of two splice variants of human phosphodiesterase 11A.". Proc. Natl. Acad. Sci. U.S.A. 97 (23): 12891–5. doi:10.1073/pnas.200355397. PMC 18860. PMID 11050148.
• Yuasa K, Kanoh Y, Okumura K, Omori K (2001). "Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains.". Eur. J. Biochem. 268 (1): 168–78. doi:10.1046/j.1432-1327.2001.01866.x. PMID 11121118.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
• Yuasa K, Ohgaru T, Asahina M, Omori K (2001). "Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants.". Eur. J. Biochem. 268 (16): 4440–8. doi:10.1046/j.1432-1327.2001.02366.x. PMID 11502204.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Weeks JL, Zoraghi R, Beasley A, et al. (2005). "High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients.". Int. J. Impot. Res. 17 (1): 5–9. doi:10.1038/sj.ijir.3901283. PMID 15538396.
• Loughney K, Taylor J, Florio VA (2005). "3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues.". Int. J. Impot. Res. 17 (4): 320–5. doi:10.1038/sj.ijir.3901317. PMID 15800651.
• Wayman C, Phillips S, Lunny C, et al. (2005). "Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology.". Int. J. Impot. Res. 17 (3): 216–23. doi:10.1038/sj.ijir.3901307. PMID 15800654.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• D'Andrea MR, Qiu Y, Haynes-Johnson D, et al. (2005). "Expression of PDE11A in normal and malignant human tissues.". J. Histochem. Cytochem. 53 (7): 895–903. doi:10.1369/jhc.5A6625.2005. PMID 15995148.
• Francis SH (2005). "Phosphodiesterase 11 (PDE11): is it a player in human testicular function?". Int. J. Impot. Res. 17 (5): 467–8. doi:10.1038/sj.ijir.3901377. PMID 16079899.
• Gross-Langenhoff M, Hofbauer K, Weber J, et al. (2006). "cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11.". J. Biol. Chem. 281 (5): 2841–6. doi:10.1074/jbc.M511468200. PMID 16330539.
• Horvath A, Boikos S, Giatzakis C, et al. (2006). "A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia.". Nat. Genet. 38 (7): 794–800. doi:10.1038/ng1809. PMID 16767104.
• Wong ML, Whelan F, Deloukas P, et al. (2006). "Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response.". Proc. Natl. Acad. Sci. U.S.A. 103 (41): 15124–9. doi:10.1073/pnas.0602795103. PMC 1581426. PMID 17008408.